Activated mononuclear cells expressing interleukin-2 (IL2) receptors (IL2-Rs) heavily infiltrate the Crohn's disease (CD) gut wall. A new technique for the in vivo detection of tissue infiltrating IL2-R positive (IL2R+ve) cells was developed based on 123I-IL2 scintigraphy. The aim of this study was to investigate whether 123I-IL2 accumulates in the CD gut wall in different phases of the disease and to evaluate the specificity of 123I-IL2 binding to activated IL2R+ve cells infiltrating the gut wall.

Signore, A., Chianelli, M., Annovazzi, A., Bonanno, E., Spagnoli, L.g., Pozzilli, P., et al. (2000). 123I-interleukin-2 scintigraphy for in vivo assessment of intestinal mononuclear cell infiltration in Crohn's disease. THE JOURNAL OF NUCLEAR MEDICINE, 41(2), 242-249.

123I-interleukin-2 scintigraphy for in vivo assessment of intestinal mononuclear cell infiltration in Crohn's disease

BONANNO, ELENA;SPAGNOLI, LUIGI GIUSTO;PALLONE, FRANCESCO;BIANCONE, LIVIA
2000-02-01

Abstract

Activated mononuclear cells expressing interleukin-2 (IL2) receptors (IL2-Rs) heavily infiltrate the Crohn's disease (CD) gut wall. A new technique for the in vivo detection of tissue infiltrating IL2-R positive (IL2R+ve) cells was developed based on 123I-IL2 scintigraphy. The aim of this study was to investigate whether 123I-IL2 accumulates in the CD gut wall in different phases of the disease and to evaluate the specificity of 123I-IL2 binding to activated IL2R+ve cells infiltrating the gut wall.
feb-2000
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/08 - ANATOMIA PATOLOGICA
English
Sensitivity and Specificity; Male; Interleukin-2; Receptors, Interleukin-2; Iodine Radioisotopes; Female; Ileum; Autoradiography; Adult; Humans; Crohn Disease; Case-Control Studies
Signore, A., Chianelli, M., Annovazzi, A., Bonanno, E., Spagnoli, L.g., Pozzilli, P., et al. (2000). 123I-interleukin-2 scintigraphy for in vivo assessment of intestinal mononuclear cell infiltration in Crohn's disease. THE JOURNAL OF NUCLEAR MEDICINE, 41(2), 242-249.
Signore, A; Chianelli, M; Annovazzi, A; Bonanno, E; Spagnoli, Lg; Pozzilli, P; Pallone, F; Biancone, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/13531
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