The present study investigated the association between genetic polymorphisms of selected thrombophilic factors with recurrent miscarriage (RM). The genetic polymorphisms for plasminogen activator inhibitor-1 4G/5G (PAI-1), Factor V Leiden (FVL), Factor II G20210A (FII) and methylenetetrahydrofolate reductase MTHFR C677T were determined in 186 RM women and 129 healthy women. In RM women, the frequency of heterozygosity for PAI-1 5G/4G (31%) was significantly higher than in controls (5G/4G: 22%) whereas no difference was found in the case of homozygosity 4G/4G and 5G/5G. The frequencies of genotype G/A for FVL and FII were significantly higher in RM women (FVL, 10%; FII, 8%) than in controls (FVL, 3%; FII, 2%). No difference was found in the case of MTHFR C677T. The polymorphisms of FVL and FII should be screened in RM women, whereas PAI-1 seems to be weakly associated with RM. The role of MTHFR C677T polymorphisms without hyperhomocysteinemia appears negligible.

Pietropolli, A., Giuliani, E., Bruno, V., Patrizi, L., Piccione, E., Ticconi, C. (2014). Plasminogen activator inhibitor-1, factor V, factor II and methylenetetrahydrofolate reductase polymorphisms in women with recurrent miscarriage. JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 34(3), 229-234 [10.3109/01443615.2013.836476].

Plasminogen activator inhibitor-1, factor V, factor II and methylenetetrahydrofolate reductase polymorphisms in women with recurrent miscarriage

PIETROPOLLI, ADALGISA;PATRIZI, LODOVICO;PICCIONE, EMILIO;TICCONI, CARLO
2014-01-01

Abstract

The present study investigated the association between genetic polymorphisms of selected thrombophilic factors with recurrent miscarriage (RM). The genetic polymorphisms for plasminogen activator inhibitor-1 4G/5G (PAI-1), Factor V Leiden (FVL), Factor II G20210A (FII) and methylenetetrahydrofolate reductase MTHFR C677T were determined in 186 RM women and 129 healthy women. In RM women, the frequency of heterozygosity for PAI-1 5G/4G (31%) was significantly higher than in controls (5G/4G: 22%) whereas no difference was found in the case of homozygosity 4G/4G and 5G/5G. The frequencies of genotype G/A for FVL and FII were significantly higher in RM women (FVL, 10%; FII, 8%) than in controls (FVL, 3%; FII, 2%). No difference was found in the case of MTHFR C677T. The polymorphisms of FVL and FII should be screened in RM women, whereas PAI-1 seems to be weakly associated with RM. The role of MTHFR C677T polymorphisms without hyperhomocysteinemia appears negligible.
2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/40 - GINECOLOGIA E OSTETRICIA
English
Abortion, Habitual; Adult; Case-Control Studies; Factor V; Female; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Plasminogen Activator Inhibitor 1; Polymorphism, Genetic; Pregnancy; Prothrombin; Thrombophilia
10.3109/01443615.2013.836476
Pietropolli, A., Giuliani, E., Bruno, V., Patrizi, L., Piccione, E., Ticconi, C. (2014). Plasminogen activator inhibitor-1, factor V, factor II and methylenetetrahydrofolate reductase polymorphisms in women with recurrent miscarriage. JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 34(3), 229-234 [10.3109/01443615.2013.836476].
Pietropolli, A; Giuliani, E; Bruno, V; Patrizi, L; Piccione, E; Ticconi, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/134584
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