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EnglishAn association between Epstein-Barr Virus (EBV) infection and lymphoproliferative diseases has been reported with EBV + diffuse large B cell-lymphoma (DLBCL) of the elderly described as a distinct entity. In a cohort of 218 human immunodeficiency virus (HIV)-negative patients with diffuse large B-cell lymphomas, we detected EBV-DNA in 25% of whole blood (WB) samples at diagnosis. Presence and viral load in WB, mononuclear cells or plasma did not predict the presence of EBV in the tumor biopsy. Positive Hepatitis C virus (HCV) serology was associated with a higher frequency of EBV in WB. Patients with EBV-DNA in WB had a significantly shorter progression-free (p = 0.02) and overall survival (p = 0.05) after immunochemotherapy with R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone). We conclude that detection of EBV in WB is not a surrogate marker for EBV-association in diffuse large B-cell lymphoma, however it associates with worse outcome.
Tisi, M.C., Cupelli, E., Santangelo, R., Maiolo, E., Alma, E., Giachelia, M., et al. (2015). Whole blood EBV-DNA predicts outcome in diffuse large B-cell lymphoma. LEUKEMIA & LYMPHOMA, 57(3), 628-634 [10.3109/10428194.2015.1072766].
| Tipologia: | Articolo su rivista | |
| Citazione: | Tisi, M.C., Cupelli, E., Santangelo, R., Maiolo, E., Alma, E., Giachelia, M., et al. (2015). Whole blood EBV-DNA predicts outcome in diffuse large B-cell lymphoma. LEUKEMIA & LYMPHOMA, 57(3), 628-634 [10.3109/10428194.2015.1072766]. | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore MED/15 - Malattie del Sangue | |
| Revisione (peer review): | Esperti anonimi | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3109/10428194.2015.1072766 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 12-ott-2015 | |
| Titolo: | Whole blood EBV-DNA predicts outcome in diffuse large B-cell lymphoma | |
| Autori: | ||
| Autori: | Tisi, MC; Cupelli, E; Santangelo, R; Maiolo, E; Alma, E; Giachelia, M; Martini, M; Bellesi, S; D'Alò, F; Voso, Mt; Pompili, M; Leone, G; Larocca, Lm; Hohaus, S | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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