Aim. To compare the diagnostic performance of diffusion weighted imaging (DWI) using b-values of 1000 s/mm(2) and 2000 s/mm(2) at 3 Tesla (T) for the evaluation of clinically significant prostate cancer. Matherials and Methods. Seventy-eight prostate cancer patients underwent a 3T MRI scan followed by radical prostatectomy. DWI was performed using b-values of 0, 1000, and 2000 s/mm(2) and qualitatively analysed by two radiologists. ADC maps were obtained at b-values of 1000 and 2000 s/mm(2) and quantitatively analyzed in consensus. Results. For diagnosis of 78 prostate cancers the accuracy of DWI for the young reader was significantly greater at b = 2000 s/mm(2) for the peripheral zone (PZ) but not for the transitional zone (TZ). For the experienced reader, DWI did not show significant differences in accuracy between b-values of 1000 and 2000 s/mm(2). The quantitative analysis in the PZ and TZ was substantially superimposable between the two b-values, albeit with a higher accuracy with a b-value of 2000 s/mm(2). Conclusions. With a b-value of 2000 s/mm(2) at 3T both readers differentiated clinical significant cancer from benign tissue; higher b-values can be helpful for the less experienced readers.

Manenti, G., Nezzo, M., Chegai, F., Vasili, E., Bonanno, E., & Simonetti, G. (2014). DWI of Prostate Cancer: Optimal b-Value in Clinical Practice. PROSTATE CANCER, 2014 [10.1155/2014/868269].

DWI of Prostate Cancer: Optimal b-Value in Clinical Practice

MANENTI, GUGLIELMO;BONANNO, ELENA;SIMONETTI, GIOVANNI MARIA EGISTO
2014

Abstract

Aim. To compare the diagnostic performance of diffusion weighted imaging (DWI) using b-values of 1000 s/mm(2) and 2000 s/mm(2) at 3 Tesla (T) for the evaluation of clinically significant prostate cancer. Matherials and Methods. Seventy-eight prostate cancer patients underwent a 3T MRI scan followed by radical prostatectomy. DWI was performed using b-values of 0, 1000, and 2000 s/mm(2) and qualitatively analysed by two radiologists. ADC maps were obtained at b-values of 1000 and 2000 s/mm(2) and quantitatively analyzed in consensus. Results. For diagnosis of 78 prostate cancers the accuracy of DWI for the young reader was significantly greater at b = 2000 s/mm(2) for the peripheral zone (PZ) but not for the transitional zone (TZ). For the experienced reader, DWI did not show significant differences in accuracy between b-values of 1000 and 2000 s/mm(2). The quantitative analysis in the PZ and TZ was substantially superimposable between the two b-values, albeit with a higher accuracy with a b-value of 2000 s/mm(2). Conclusions. With a b-value of 2000 s/mm(2) at 3T both readers differentiated clinical significant cancer from benign tissue; higher b-values can be helpful for the less experienced readers.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/36 - Diagnostica per Immagini e Radioterapia
eng
10.1155/2014/868269
Manenti, G., Nezzo, M., Chegai, F., Vasili, E., Bonanno, E., & Simonetti, G. (2014). DWI of Prostate Cancer: Optimal b-Value in Clinical Practice. PROSTATE CANCER, 2014 [10.1155/2014/868269].
Manenti, G; Nezzo, M; Chegai, F; Vasili, E; Bonanno, E; Simonetti, Gme
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/134391
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