A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OR(Overall) = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.

Riveira Munoz, E., He, S., Escaramís, G., Stuart, P., Hüffmeier, U., Lee, C., et al. (2011). Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(5), 1105-1109 [10.1038/jid.2010.350].

Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.

GIARDINA, EMILIANO;NOVELLI, GIUSEPPE;
2011-01-01

Abstract

A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OR(Overall) = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.
2011
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/03 - GENETICA MEDICA
English
Con Impact Factor ISI
Riveira Munoz, E., He, S., Escaramís, G., Stuart, P., Hüffmeier, U., Lee, C., et al. (2011). Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(5), 1105-1109 [10.1038/jid.2010.350].
Riveira Munoz, E; He, S; Escaramís, G; Stuart, P; Hüffmeier, U; Lee, C; Kirby, B; Oka, A; Giardina, E; Liao, W; Bergboer, J; Kainu, K; de Cid, R; Munkhbat, B; Zeeuwen, P; Armour, J; Poon, A; Mabuchi, T; Ozawa, A; Zawirska, A; Burden, A; Barker, J; Capon, F; Traupe, H; Sun, L; Cui, Y; Yin, X; Chen, G; Lim, H; Nair, R; Voorhees, J; Tejasvi, T; Pujol, R; Munkhtuvshin, N; Fischer, J; Kere, J; Schalkwijk, J; Bowcock, A; Kwok, P; Novelli, G; Inoko, H; Ryan, A; Trembath, R; Reis, A; Zhang, X; Elder, J; Estivill, X
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/134268
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 83
  • ???jsp.display-item.citation.isi??? 78
social impact