The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community. Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations of pathogens do not necessarily imply a low level of risk for the patient and so the overall challenge of minimising risk remains. This review aims to discuss the variable level of pathogenic risk and describes the current screening methods used to prevent/detect the presence of pathogens in blood/plasma-derived products.

Di Minno, G., Perno, C.F., Tiede, A., Navarro, D., Canaro, M., Guertler, L., et al. (2016). Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders. BLOOD REVIEWS [10.1016/j.blre.2015.07.004].

Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders

PERNO, CARLO FEDERICO;
2016

Abstract

The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community. Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations of pathogens do not necessarily imply a low level of risk for the patient and so the overall challenge of minimising risk remains. This review aims to discuss the variable level of pathogenic risk and describes the current screening methods used to prevent/detect the presence of pathogens in blood/plasma-derived products.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - Microbiologia e Microbiologia Clinica
English
Blood safety; Clotting; Haemophilia; Pathogen; Transfusion
Di Minno, G., Perno, C.F., Tiede, A., Navarro, D., Canaro, M., Guertler, L., et al. (2016). Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders. BLOOD REVIEWS [10.1016/j.blre.2015.07.004].
Di Minno, G; Perno, Cf; Tiede, A; Navarro, D; Canaro, M; Guertler, L; Ironside, J
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/133690
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