Compared with NMDA receptor-dependent LTP, much less is known about the mechanism of induction of NMDA receptor-independent LTP; the most extensively studied form of which is mossy fiber LTP in the hippocampus. In the present study we show that Ca2+-induced Ca2+ release from intracellular stores is involved in the induction of mossy fiber LTP. This release also contributes to the kainate receptor-dependent component of the pronounced synaptic facilitation that occurs during high-frequency stimulation. We also present evidence that the trigger for this Ca2+ release is Ca2+ permeation through kainate receptors. However, these novel synaptic mechanisms can be bypassed when the Ca2+ concentration is raised (from 2 to 4 mM), via a compensatory involvement of L-type Ca2+ channels. These findings suggest that presynaptic kainate receptors at mossy fiber synapses can initiate a cascade involving Ca2+ release from intracellular stores that is important in both short-term and long-term plasticity.

Lauri, S., Bortolotto, Z., NISTICO', R.G., Bleakman, D., Ornstein, P., Lodge, D., et al. (2003). A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. NEURON, 39(2), 327-341 [10.1016/S0896-6273(03)00369-6].

A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus

NISTICO', ROBERT GIOVANNI;
2003-07-17

Abstract

Compared with NMDA receptor-dependent LTP, much less is known about the mechanism of induction of NMDA receptor-independent LTP; the most extensively studied form of which is mossy fiber LTP in the hippocampus. In the present study we show that Ca2+-induced Ca2+ release from intracellular stores is involved in the induction of mossy fiber LTP. This release also contributes to the kainate receptor-dependent component of the pronounced synaptic facilitation that occurs during high-frequency stimulation. We also present evidence that the trigger for this Ca2+ release is Ca2+ permeation through kainate receptors. However, these novel synaptic mechanisms can be bypassed when the Ca2+ concentration is raised (from 2 to 4 mM), via a compensatory involvement of L-type Ca2+ channels. These findings suggest that presynaptic kainate receptors at mossy fiber synapses can initiate a cascade involving Ca2+ release from intracellular stores that is important in both short-term and long-term plasticity.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14
English
2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Arthropod Venoms; Calcium; Calcium Channel Blockers; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Space; In Vitro Techniques; Isoquinolines; Kainic Acid; Long-Term Potentiation; Magnesium; Membrane Potentials; Mossy Fibers, Hippocampal; Nifedipine; Patch-Clamp Techniques; Rats; Receptors, Kainic Acid; Ryanodine; Synaptic Transmission; Thapsigargin
Lauri, S., Bortolotto, Z., NISTICO', R.G., Bleakman, D., Ornstein, P., Lodge, D., et al. (2003). A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. NEURON, 39(2), 327-341 [10.1016/S0896-6273(03)00369-6].
Lauri, S; Bortolotto, Z; Nistico', Rg; Bleakman, D; Ornstein, P; Lodge, D; Isaac, J; Collingridge, G
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
NEURON 2003 A ROLE FOR CA.pdf

accesso aperto

Descrizione: A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus
Licenza: Copyright dell'editore
Dimensione 571.42 kB
Formato Adobe PDF
571.42 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/133222
Citazioni
  • ???jsp.display-item.citation.pmc??? 68
  • Scopus 162
  • ???jsp.display-item.citation.isi??? 151
social impact