Reactive oxygen species (ROS) have been postulated to play a crucial role in the pathogenesis of ischaemia-reperfusion injury. Among these, hydrogen peroxide (H(2)O(2)) is known to be a toxic compound responsible for free-radical-dependent neuronal damage. In recent years, however, the 'bad reputation' of H(2)O(2) and other ROS molecules has changed. The aim of this study was to assess the protective role of H(2)O(2) and modification in its endogenous production on the electrophysiological and morphological changes induced by oxygen/glucose deprivation (OGD) on CA1 hippocampal neurons.
Nistico', R.g., Piccirilli, S., Cucchiaroni, M.l., Armogida, M., Guatteo, E., Giampa, C., et al. (2008). Neuroprotective effect of hydrogen peroxide on an in vitro model of brain ischaemia. BRITISH JOURNAL OF PHARMACOLOGY, 153(5), 1022-1029 [10.1038/sj.bjp.0707587].
Neuroprotective effect of hydrogen peroxide on an in vitro model of brain ischaemia
NISTICO', ROBERT GIOVANNI;PICCIRILLI, SILVIA;CUCCHIARONI, MARIA LETIZIA;BERNARDI, GIORGIO;MERCURI, NICOLA BIAGIO
2008-01-01
Abstract
Reactive oxygen species (ROS) have been postulated to play a crucial role in the pathogenesis of ischaemia-reperfusion injury. Among these, hydrogen peroxide (H(2)O(2)) is known to be a toxic compound responsible for free-radical-dependent neuronal damage. In recent years, however, the 'bad reputation' of H(2)O(2) and other ROS molecules has changed. The aim of this study was to assess the protective role of H(2)O(2) and modification in its endogenous production on the electrophysiological and morphological changes induced by oxygen/glucose deprivation (OGD) on CA1 hippocampal neurons.| File | Dimensione | Formato | |
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Descrizione: Neuroprotective effect of hydrogen peroxide on an in vitro model of brain ischaemia
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