B6-Tg/Thy1APP23Sdz (APP23) mutant mice exhibit neurohistological hallmarks of Alzheimer's disease but show intact basal hippocampal neurotransmission and synaptic plasticity. Here, we examine whether spatial learning differently modifies the structural and electrophysiological properties of hippocampal synapses in APP23 and wild-type mice. While no genotypic difference was found in the pseudotrained mice, training elicited a stronger increase in spine density and a more rapid decay of long-term potentiation (LTP) in APP23 mutants. Thus, learning discloses mutation-related abnormalities regarding dendritic spine formation and LTP persistence, thereby suggesting that although unaltered in naïve synapses, plasticity becomes defective at the time it comes into play.

Middei, S., Roberto, A., Berretta, N., Panico, M., Lista, S., Bernardi, G., et al. (2010). Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer's disease. LEARNING & MEMORY, 17(5), 236-240 [10.1101/lm.1748310].

Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer's disease

BERNARDI, GIORGIO;MERCURI, NICOLA BIAGIO;NISTICO', ROBERT GIOVANNI
2010-01-01

Abstract

B6-Tg/Thy1APP23Sdz (APP23) mutant mice exhibit neurohistological hallmarks of Alzheimer's disease but show intact basal hippocampal neurotransmission and synaptic plasticity. Here, we examine whether spatial learning differently modifies the structural and electrophysiological properties of hippocampal synapses in APP23 and wild-type mice. While no genotypic difference was found in the pseudotrained mice, training elicited a stronger increase in spine density and a more rapid decay of long-term potentiation (LTP) in APP23 mutants. Thus, learning discloses mutation-related abnormalities regarding dendritic spine formation and LTP persistence, thereby suggesting that although unaltered in naïve synapses, plasticity becomes defective at the time it comes into play.
2010
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14 - FARMACOLOGIA
English
Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Biophysics; Dendritic Spines; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Humans; In Vitro Techniques; Learning Disorders; Locomotion; Long-Term Potentiation; Maze Learning; Mice; Mice, Transgenic; Mutation; Neurons; Patch-Clamp Techniques; Reaction Time; Silver Staining; Time Factors; Alzheimer Disease
Middei, S., Roberto, A., Berretta, N., Panico, M., Lista, S., Bernardi, G., et al. (2010). Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer's disease. LEARNING & MEMORY, 17(5), 236-240 [10.1101/lm.1748310].
Middei, S; Roberto, A; Berretta, N; Panico, M; Lista, S; Bernardi, G; Mercuri, Nb; Ammassari Teule, M; Nistico', Rg
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/133182
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