Idiopathic pulmonary fibrosis has been associated with emphysema in cigarette smokers as a new clinical entity: combined pulmonary fibrosis and emphysema (CPFE). In order to compare histomorphometrical, roentgenological and immunohistochemical aspects of usual interstitial pneumonia (UIP) with and without associated pulmonary emphysema, 17 patients with biopsy-proven UIP were evaluated. Morphometrical evaluation of lung parenchyma destruction was used to divide patients in two subgroups: emphysema/UIP (n=9) and UIP alone (n=8); four patients with biopsy-proven emphysema without fibrosis were also evaluated. At HRTC scan, emphysematous lesions were prevalent in the upper fields of both emphysema/UIP and emphysema groups and the distribution of fibrotic lesions was similar in emphysema/UIP compared to UIP alone. The semiquantitative histopathological fibrotic score was also similar in emphysema/UIP and UIP alone. In addition, the expression of tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-2, MMP-9, MMP-7 and membrane type 1-metalloproteinase (MT1-MMP) by fibroblasts of myofibroblastic foci was similar in emphysema/UIP and UIP alone patients. In contrast, fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2, MMP-9, MMP-7 and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects, in the presence of similar levels of TIMP-1, TIMP-2 and TNF-alpha. Fibrotic and emphysematous lesions in emphysema/UIP patients appear to follow the roentgenological and histopathological patterns expected for either UIP or emphysema. Interstitial fibroblast activation is more pronounced in the areas of lung destruction in emphysema/UIP compared to those with emphysema alone, as for exaggerated tissue remodeling.

Rogliani, P., Mura, M., Mattia, P., Ferlosio, A., Farinelli, G., Mariotta, S., et al. (2008). HRCT and histopathological evaluation of fibrosis and tissue destruction in IPF associated with pulmonary emphysema. RESPIRATORY MEDICINE, 102(12), 1753-1761 [10.1016/j.rmed.2008.07.010].

HRCT and histopathological evaluation of fibrosis and tissue destruction in IPF associated with pulmonary emphysema

ROGLIANI, PAOLA;FERLOSIO, AMEDEO;SALTINI, CESARE;ORLANDI, AUGUSTO
2008-12-01

Abstract

Idiopathic pulmonary fibrosis has been associated with emphysema in cigarette smokers as a new clinical entity: combined pulmonary fibrosis and emphysema (CPFE). In order to compare histomorphometrical, roentgenological and immunohistochemical aspects of usual interstitial pneumonia (UIP) with and without associated pulmonary emphysema, 17 patients with biopsy-proven UIP were evaluated. Morphometrical evaluation of lung parenchyma destruction was used to divide patients in two subgroups: emphysema/UIP (n=9) and UIP alone (n=8); four patients with biopsy-proven emphysema without fibrosis were also evaluated. At HRTC scan, emphysematous lesions were prevalent in the upper fields of both emphysema/UIP and emphysema groups and the distribution of fibrotic lesions was similar in emphysema/UIP compared to UIP alone. The semiquantitative histopathological fibrotic score was also similar in emphysema/UIP and UIP alone. In addition, the expression of tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-2, MMP-9, MMP-7 and membrane type 1-metalloproteinase (MT1-MMP) by fibroblasts of myofibroblastic foci was similar in emphysema/UIP and UIP alone patients. In contrast, fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2, MMP-9, MMP-7 and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects, in the presence of similar levels of TIMP-1, TIMP-2 and TNF-alpha. Fibrotic and emphysematous lesions in emphysema/UIP patients appear to follow the roentgenological and histopathological patterns expected for either UIP or emphysema. Interstitial fibroblast activation is more pronounced in the areas of lung destruction in emphysema/UIP compared to those with emphysema alone, as for exaggerated tissue remodeling.
dic-2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
English
Con Impact Factor ISI
Tomography, X-Ray Computed; Male; Middle Aged; Female; Total Lung Capacity; Pulmonary Emphysema; Carbon Dioxide; Humans; Partial Pressure; Matrix Metalloproteinases; Respiratory Function Tests; Tissue Inhibitor of Metalloproteinases; Oxygen; Pulmonary Fibrosis; Aged
Rogliani, P., Mura, M., Mattia, P., Ferlosio, A., Farinelli, G., Mariotta, S., et al. (2008). HRCT and histopathological evaluation of fibrosis and tissue destruction in IPF associated with pulmonary emphysema. RESPIRATORY MEDICINE, 102(12), 1753-1761 [10.1016/j.rmed.2008.07.010].
Rogliani, P; Mura, M; Mattia, P; Ferlosio, A; Farinelli, G; Mariotta, S; Graziano, P; Pezzuto, G; Ricci, A; Saltini, C; Orlandi, A
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
resp med.pdf

accesso aperto

Descrizione: articolo pdf
Dimensione 548.37 kB
Formato Adobe PDF
548.37 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/13315
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 53
  • ???jsp.display-item.citation.isi??? 43
social impact