The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irreversible collagen stabilization in liver fibrosis, although functional evidence is lacking. We studied the contribution of TG2 to hepatic fibrotic matrix stability, as well as liver fibrosis progression and regression in TG2-deficient mice.

Popov, Y., Sverdlov, D., Sharma, A., Bhaskar, K., Li, S., Freitag, T., et al. (2011). Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice. GASTROENTEROLOGY, 140(5), 1642-1652 [10.1053/j.gastro.2011.01.040].

Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice

MELINO, GENNARO;
2011-01-01

Abstract

The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irreversible collagen stabilization in liver fibrosis, although functional evidence is lacking. We studied the contribution of TG2 to hepatic fibrotic matrix stability, as well as liver fibrosis progression and regression in TG2-deficient mice.
2011
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
English
Animals; Apoptosis; Disease Progression; Extracellular Matrix; GTP-Binding Proteins; Liver; Liver Cirrhosis, Experimental; Mice; Mice, Inbred C57BL; RNA; Reverse Transcriptase Polymerase Chain Reaction; Transglutaminases; Gene Expression Regulation
Popov, Y., Sverdlov, D., Sharma, A., Bhaskar, K., Li, S., Freitag, T., et al. (2011). Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice. GASTROENTEROLOGY, 140(5), 1642-1652 [10.1053/j.gastro.2011.01.040].
Popov, Y; Sverdlov, D; Sharma, A; Bhaskar, K; Li, S; Freitag, T; Lee, J; Dieterich, W; Melino, G; Schuppan, D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/131898
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