p63 is a transcriptional factor belonging to p53 family of genes. Beside the role in cancer, partially shared with p53 and the other member p73, p63 also plays exclusive roles in development and homeostasis of ectodermal/epidermal-related organs. Here we show that p63 transcriptionally controls the expression of the matrix metallopeptidase 13 (MMP13). p63 binds a p53-like responsive element in the human promoter of MMP13, thus promoting the activation of its transcription. The catalytic activity of MMP13 is required in high invasion capacity of metastatic cancer cells, however, although p63 and MMP13 expression correlates in cancer patients, their co-expression does not predict cancer patient survival. Our results demonstrate that p63 directly controls MMP13 expression.

Celardo, M.t., Antonov, A., Amelio, I., Annicchiarico Petruzzelli, M., & Melino, G. (2014). p63 transcriptionally regulates the expression of matrix metallopeptidase 13. ONCOTARGET, 5(5), 1279-1289.

p63 transcriptionally regulates the expression of matrix metallopeptidase 13

CELARDO, MARIA TERESA;Amelio, I;MELINO, GENNARO
2014-03-15

Abstract

p63 is a transcriptional factor belonging to p53 family of genes. Beside the role in cancer, partially shared with p53 and the other member p73, p63 also plays exclusive roles in development and homeostasis of ectodermal/epidermal-related organs. Here we show that p63 transcriptionally controls the expression of the matrix metallopeptidase 13 (MMP13). p63 binds a p53-like responsive element in the human promoter of MMP13, thus promoting the activation of its transcription. The catalytic activity of MMP13 is required in high invasion capacity of metastatic cancer cells, however, although p63 and MMP13 expression correlates in cancer patients, their co-expression does not predict cancer patient survival. Our results demonstrate that p63 directly controls MMP13 expression.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
eng
Breast Neoplasms; Cell Line; Humans; Kaplan-Meier Estimate; Matrix Metalloproteinase 13; Melanoma; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Gene Expression Regulation; Transcription, Genetic
Celardo, M.t., Antonov, A., Amelio, I., Annicchiarico Petruzzelli, M., & Melino, G. (2014). p63 transcriptionally regulates the expression of matrix metallopeptidase 13. ONCOTARGET, 5(5), 1279-1289.
Celardo, Mt; Antonov, A; Amelio, I; Annicchiarico Petruzzelli, M; Melino, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/131893
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