The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.

Levine, A.J., Tomasini, R., Mckeon, F.D., Mak, T.W., & Melino, G. (2011). The p53 family: Guardians of maternal reproduction. NATURE REVIEWS. MOLECULAR CELL BIOLOGY, 12(4), 259-265 [10.1038/nrm3086].

The p53 family: Guardians of maternal reproduction

MELINO, GENNARO
2011

Abstract

The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.
Pubblicato
Rilevanza internazionale
Editoriale
Esperti anonimi
Settore BIO/10
eng
Animals; Blastocyst; DNA-Binding Proteins; Female; Fertility; Humans; Male; Mice; Mice, Knockout; Models, Biological; Nuclear Proteins; Oocytes; Phosphoproteins; Reproduction; Trans-Activators; Transcription Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins
Levine, A.J., Tomasini, R., Mckeon, F.D., Mak, T.W., & Melino, G. (2011). The p53 family: Guardians of maternal reproduction. NATURE REVIEWS. MOLECULAR CELL BIOLOGY, 12(4), 259-265 [10.1038/nrm3086].
Levine, AJ; Tomasini, R; Mckeon, FD; Mak, TW; Melino, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/131866
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