Autophagy is a self-digesting mechanism that cells adopt to respond to stressful stimuli. Morphologically, cells dying by autophagy show multiple cytoplasmic double-membraned vacuoles, and, if prolonged, autophagy can lead to cell death, "autophagic cell death". Thus, autophagy can act both as a temporary protective mechanism during a brief stressful episode and be a mode of cell death in its own right. In this mini-review we focus on recent knowledge concerning the connection between autophagy and programmed cell death, evaluating their possible implications for therapy in pathologies like cancer and neurodegeneration.

Melino, G., Amelio, I., Melino, G., Knight, R. (2011). Cell death pathology: Cross-talk with autophagy and its clinical implications. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 414(2), 277-281 [10.1016/j.bbrc.2011.09.080].

Cell death pathology: Cross-talk with autophagy and its clinical implications

MELINO, GENNARO;Amelio, I;
2011

Abstract

Autophagy is a self-digesting mechanism that cells adopt to respond to stressful stimuli. Morphologically, cells dying by autophagy show multiple cytoplasmic double-membraned vacuoles, and, if prolonged, autophagy can lead to cell death, "autophagic cell death". Thus, autophagy can act both as a temporary protective mechanism during a brief stressful episode and be a mode of cell death in its own right. In this mini-review we focus on recent knowledge concerning the connection between autophagy and programmed cell death, evaluating their possible implications for therapy in pathologies like cancer and neurodegeneration.
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore BIO/10
English
Autophagy; Cell Death; Cell Survival; Humans; Neoplasms; Neurodegenerative Diseases
Melino, G., Amelio, I., Melino, G., Knight, R. (2011). Cell death pathology: Cross-talk with autophagy and its clinical implications. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 414(2), 277-281 [10.1016/j.bbrc.2011.09.080].
Melino, G; Amelio, I; Melino, G; Knight, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/131850
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