The catalytic activity of the vanadium-dependent bromoperoxidase isolated from the brown alga Ascophyllum nodosum is compared with the activity of a cheap, commercially available V-catalyst precursor in the bromination of thymol. Organic solvents have been avoided to make the system appealing from a sustainable chemistry point of view. It is noteworthy that, notwithstanding the low solubility of the substrate, the thymol bromination reactions were performed in water, with a safe brominating source, under mild conditions, and with relatively inexpensive reagents. In this regard, the greenness of the systems was evaluated by the estimation of the E-factor value; the result is that the chemical reaction has a lower environmental impact than the enzymatic process, with an E-factor in the range of ecofriendly processes.

Sabuzi, F., Churakova, E., Galloni, P., Wever, R., Hollmann, F., Floris, B., et al. (2015). Thymol Bromination - A Comparison between Enzymatic and Chemical Catalysis. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2015(21), 3519-3525 [10.1002/ejic.201500086].

Thymol Bromination - A Comparison between Enzymatic and Chemical Catalysis

GALLONI, PIERLUCA;FLORIS, BARBARA;CONTE, VALERIA
2015

Abstract

The catalytic activity of the vanadium-dependent bromoperoxidase isolated from the brown alga Ascophyllum nodosum is compared with the activity of a cheap, commercially available V-catalyst precursor in the bromination of thymol. Organic solvents have been avoided to make the system appealing from a sustainable chemistry point of view. It is noteworthy that, notwithstanding the low solubility of the substrate, the thymol bromination reactions were performed in water, with a safe brominating source, under mild conditions, and with relatively inexpensive reagents. In this regard, the greenness of the systems was evaluated by the estimation of the E-factor value; the result is that the chemical reaction has a lower environmental impact than the enzymatic process, with an E-factor in the range of ecofriendly processes.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/06 - Chimica Organica
English
Vanadium / Enzyme catalysis / V-bromoperoxidases / Sustainable chemistry / Bromination / Thymol
COST Action CM1003 “Biological Oxidation Reactions – Mechanisms and Design of New Catalysts”
http://onlinelibrary.wiley.com/doi/10.1002/ejic.201500086/abstract
Sabuzi, F., Churakova, E., Galloni, P., Wever, R., Hollmann, F., Floris, B., et al. (2015). Thymol Bromination - A Comparison between Enzymatic and Chemical Catalysis. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2015(21), 3519-3525 [10.1002/ejic.201500086].
Sabuzi, F; Churakova, E; Galloni, P; Wever, R; Hollmann, F; Floris, B; Conte, V
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/131826
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