Multiple sclerosis (MS) is a complex, multifactorial disease associated with damage to the axonal myelin sheaths and neuronal degeneration. The pathognomonic event in MS is oligodendrocyte loss accompanied by axonal damage, blood-brain barrier leakage, inflammation and infiltration of immune cells. The etiopathogenesis of MS is far from being elucidated. However, increasing evidence suggests that the inflammatory and apoptotic responses, occurring in patients either at the peripheral level or the central nervous system (CNS), can play a role. In this review, we give a comprehensive picture of general aspects of inflammation and apoptosis in MS, with special emphasis on the until now not well highlighted possible links between phenomena relevant to these aspects occurring in either the periphery or in the CNS during MS.

Macchi, B., Marino Merlo, F., Nocentini, U., Pisani, V., Cuzzocrea, S., Grelli, S., et al. (2015). Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system. JOURNAL OF NEUROIMMUNOLOGY, 287, 80-87 [10.1016/j.jneuroim.2015.08.016].

Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system

MACCHI, BEATRICE;NOCENTINI, UGO;GRELLI, SANDRO;
2015-10-15

Abstract

Multiple sclerosis (MS) is a complex, multifactorial disease associated with damage to the axonal myelin sheaths and neuronal degeneration. The pathognomonic event in MS is oligodendrocyte loss accompanied by axonal damage, blood-brain barrier leakage, inflammation and infiltration of immune cells. The etiopathogenesis of MS is far from being elucidated. However, increasing evidence suggests that the inflammatory and apoptotic responses, occurring in patients either at the peripheral level or the central nervous system (CNS), can play a role. In this review, we give a comprehensive picture of general aspects of inflammation and apoptosis in MS, with special emphasis on the until now not well highlighted possible links between phenomena relevant to these aspects occurring in either the periphery or in the CNS during MS.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14
Settore MED/26 - Neurologia
English
Con Impact Factor ISI
Apoptosis; Inflammation; Multiple sclerosis; Targeted therapy
Macchi, B., Marino Merlo, F., Nocentini, U., Pisani, V., Cuzzocrea, S., Grelli, S., et al. (2015). Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system. JOURNAL OF NEUROIMMUNOLOGY, 287, 80-87 [10.1016/j.jneuroim.2015.08.016].
Macchi, B; Marino Merlo, F; Nocentini, U; Pisani, V; Cuzzocrea, S; Grelli, S; Mastino, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/130651
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