Using mature (12 months), old (70 months) rabbits and 3H-labeled spiroperidol, the characteristics of renal artery dopamine receptors were studied. In old age the dissociation constant of [3H]spiroperidol was unchanged, while maximum specific binding was reduced more than 45%. The present data seem to indicate an impairment of peripheral dopaminergic function in ageing.

Collier, W., Iacopino, L., Amenta, F. (1984). Changes of [3H]spiroperidol binding in the renal artery of aged rabbits. MECHANISMS OF AGEING AND DEVELOPMENT, 28(1), 41-5.

Changes of [3H]spiroperidol binding in the renal artery of aged rabbits

IACOPINO, LEONARDO;
1984-11-01

Abstract

Using mature (12 months), old (70 months) rabbits and 3H-labeled spiroperidol, the characteristics of renal artery dopamine receptors were studied. In old age the dissociation constant of [3H]spiroperidol was unchanged, while maximum specific binding was reduced more than 45%. The present data seem to indicate an impairment of peripheral dopaminergic function in ageing.
nov-1984
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Male; Renal Artery; Spiperone; Cyclic AMP; Receptors, Dopamine; Animals; Rabbits; Dopamine; Aging; Butyrophenones
Collier, W., Iacopino, L., Amenta, F. (1984). Changes of [3H]spiroperidol binding in the renal artery of aged rabbits. MECHANISMS OF AGEING AND DEVELOPMENT, 28(1), 41-5.
Collier, W; Iacopino, L; Amenta, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/13020
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