Using mature (12 months), old (70 months) rabbits and 3H-labeled spiroperidol, the characteristics of renal artery dopamine receptors were studied. In old age the dissociation constant of [3H]spiroperidol was unchanged, while maximum specific binding was reduced more than 45%. The present data seem to indicate an impairment of peripheral dopaminergic function in ageing.
Collier, W., Iacopino, L., Amenta, F. (1984). Changes of [3H]spiroperidol binding in the renal artery of aged rabbits. MECHANISMS OF AGEING AND DEVELOPMENT, 28(1), 41-5.
Changes of [3H]spiroperidol binding in the renal artery of aged rabbits
IACOPINO, LEONARDO;
1984-11-01
Abstract
Using mature (12 months), old (70 months) rabbits and 3H-labeled spiroperidol, the characteristics of renal artery dopamine receptors were studied. In old age the dissociation constant of [3H]spiroperidol was unchanged, while maximum specific binding was reduced more than 45%. The present data seem to indicate an impairment of peripheral dopaminergic function in ageing.File in questo prodotto:
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