Cell organization is governed and maintained via specific interactions among its constituent macromolecules. Comparison of the experimentally determined protein interaction networks in different model organisms has revealed little conservation of the specific edges linking ortholog proteins. Nevertheless, some topological characteristics of the graphs representing the networks--namely non-random degree distribution and high clustering coefficient--are shared by networks of distantly related organisms. Here we investigate the role of the topological features of the protein interaction network in promoting cell organization.
Galeota, E., Gravila, C., Castiglione, F., Bernaschi, M., Cesareni, G. (2015). The hierarchical organization of natural protein interaction networks confers self-organization properties on pseudocells. BMC SYSTEMS BIOLOGY, 9 Suppl 3(Suppl 3), S3 [10.1186/1752-0509-9-S3-S3].
The hierarchical organization of natural protein interaction networks confers self-organization properties on pseudocells
BERNASCHI, MASSIMO;CESARENI, GIOVANNI
2015-01-01
Abstract
Cell organization is governed and maintained via specific interactions among its constituent macromolecules. Comparison of the experimentally determined protein interaction networks in different model organisms has revealed little conservation of the specific edges linking ortholog proteins. Nevertheless, some topological characteristics of the graphs representing the networks--namely non-random degree distribution and high clustering coefficient--are shared by networks of distantly related organisms. Here we investigate the role of the topological features of the protein interaction network in promoting cell organization.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
