TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation. This assumption is based on biochemical evidence of activation of anabolic metabolism, with enhanced pentose phosphate shunt (PPP) and nucleotide biosynthesis. Here, while we confirm that TAp73 expression enhances anabolism, we also substantiate its role in inhibiting proliferation and promoting cell death. Hence, we would like to propose an alternative interpretation of the accumulating data linking p73 to cellular metabolism: we suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation.

Agostini, M., Niklison Chirou, M., Catani, M.v., Knight, R., Melino, G., Rufini, A. (2014). TAp73 promotes anti-senescence-anabolism not proliferation. AGING, 6(11), 921-930.

TAp73 promotes anti-senescence-anabolism not proliferation

AGOSTINI, MASSIMILIANO;CATANI, MARIA VALERIA;MELINO, GENNARO;RUFINI, ALESSANDRO
2014

Abstract

TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation. This assumption is based on biochemical evidence of activation of anabolic metabolism, with enhanced pentose phosphate shunt (PPP) and nucleotide biosynthesis. Here, while we confirm that TAp73 expression enhances anabolism, we also substantiate its role in inhibiting proliferation and promoting cell death. Hence, we would like to propose an alternative interpretation of the accumulating data linking p73 to cellular metabolism: we suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
English
Animals; Bone Neoplasms; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cerebral Cortex; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Hippocampus; Humans; Mice, Inbred C57BL; Mice, Knockout; Nuclear Proteins; Nucleotides; Osteosarcoma; Pentose Phosphate Pathway; Signal Transduction; Time Factors; Transfection; Tumor Suppressor Proteins; Cell Aging; Cell Proliferation; Energy Metabolism
Agostini, M., Niklison Chirou, M., Catani, M.v., Knight, R., Melino, G., Rufini, A. (2014). TAp73 promotes anti-senescence-anabolism not proliferation. AGING, 6(11), 921-930.
Agostini, M; Niklison Chirou, M; Catani, Mv; Knight, R; Melino, G; Rufini, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/128912
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