Objectives: To evaluate the performance of biolimus-eluting stent (BES) in patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) in a real world clinical scenario. Background: Randomized studies suggest that the BES with biodegradable polymer is more effective and safe than early generation coronary stents in patients with STEMI. Methods: We included all consecutive STEMI patients undergoing PCI in this prospective, multicenter registry. The primary endpoint of the study was the rate of major adverse cardiac events (MACE), a composite of cardiac death, recurrent myocardial infarction and ischemia-driven target vessel revascularization at 1-year follow-up. Results: Between June and December 2012 we enrolled 311 STEMI patients. The primary endpoint occurred in 3.2% (95% confidence interval: 1.6–5.8) of patients: cardiac death, re-infarction, and ischemiadriven TVR occurred in 2.3%, 1.3%, and 0.6% of patients, respectively. One-year MACE-free survival was 96.8a.0%. Conclusions: In a real-world cohort of STEMI patients undergoing PCI, the use of BES is associated with good 1-year clinical outcome. These results confirm and expand previous findings showing the efficacy and safety of BES in the setting of randomized trials.

Tomai, F., De Luca, L., Altamura, L., Versaci, F., Pennacchi, M., Proietti, I., et al. (2015). One-year outcome from an all-comers population of patients with st-segment elevation myocardial infarction treated with biolimus-eluting stent with biodegradable polymer. CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 85(3), 352-358 [10.1002/ccd.25627].

One-year outcome from an all-comers population of patients with st-segment elevation myocardial infarction treated with biolimus-eluting stent with biodegradable polymer

VERSACI, FRANCESCO;
2015-01-01

Abstract

Objectives: To evaluate the performance of biolimus-eluting stent (BES) in patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) in a real world clinical scenario. Background: Randomized studies suggest that the BES with biodegradable polymer is more effective and safe than early generation coronary stents in patients with STEMI. Methods: We included all consecutive STEMI patients undergoing PCI in this prospective, multicenter registry. The primary endpoint of the study was the rate of major adverse cardiac events (MACE), a composite of cardiac death, recurrent myocardial infarction and ischemia-driven target vessel revascularization at 1-year follow-up. Results: Between June and December 2012 we enrolled 311 STEMI patients. The primary endpoint occurred in 3.2% (95% confidence interval: 1.6–5.8) of patients: cardiac death, re-infarction, and ischemiadriven TVR occurred in 2.3%, 1.3%, and 0.6% of patients, respectively. One-year MACE-free survival was 96.8a.0%. Conclusions: In a real-world cohort of STEMI patients undergoing PCI, the use of BES is associated with good 1-year clinical outcome. These results confirm and expand previous findings showing the efficacy and safety of BES in the setting of randomized trials.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
English
Con Impact Factor ISI
ST-elevation myocardial infarction; biodegradable polymer; biolimus-eluting stent; real-world registry
Tomai, F., De Luca, L., Altamura, L., Versaci, F., Pennacchi, M., Proietti, I., et al. (2015). One-year outcome from an all-comers population of patients with st-segment elevation myocardial infarction treated with biolimus-eluting stent with biodegradable polymer. CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 85(3), 352-358 [10.1002/ccd.25627].
Tomai, F; De Luca, L; Altamura, L; Versaci, F; Pennacchi, M; Proietti, I; Ghini, A; Corvo, P; De Persio, G; Petrolini, A; Tommasino, A; Sardella, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/128296
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