Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies.

Agostini, M., Tucci, P., & Melino, G. (2011). Cell death pathology: Perspective for human diseases. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 414(3), 451-455 [10.1016/j.bbrc.2011.09.081].

Cell death pathology: Perspective for human diseases

AGOSTINI, MASSIMILIANO;MELINO, GENNARO
2011

Abstract

Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/11
English
Apoptosis; Clinical Trials as Topic; Humans; Immune System Diseases; Neurodegenerative Diseases
Agostini, M., Tucci, P., & Melino, G. (2011). Cell death pathology: Perspective for human diseases. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 414(3), 451-455 [10.1016/j.bbrc.2011.09.081].
Agostini, M; Tucci, P; Melino, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/127841
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