Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies.
Agostini, M., Tucci, P., Melino, G. (2011). Cell death pathology: Perspective for human diseases. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 414(3), 451-455 [10.1016/j.bbrc.2011.09.081].
Cell death pathology: Perspective for human diseases
AGOSTINI, MASSIMILIANO;MELINO, GENNARO
2011-01-01
Abstract
Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
