The effects of an extract from Citrus bergamia (BSext) and those of two products purified from the same extract, that is, nomilin and limonin, and reference compounds, towards HTLV-1 have been reported. Moreover, they were also compared with those obtained towards HIV-1. Results showed that the efficacy of both BSext and limonin in inhibiting HTLV-1 as well as HIV-1 expression in infected cells, as evaluated by comparable quantitative assays, was close to that of the effective, reference compounds, respectively. The protective effect of BSext and of the purified products was associated with the inhibition of both HTLV-1 and HIV-1 RT activities in conceptually similar, cell-free assays. The cytotoxicity of the assayed compounds of natural origin was substantially less pronounced than that of the reference compounds, thus showing a favourable selectivity index for the novel BSext product.

Balestrieri, E., Pizzimenti, F., Ferlazzo, A., Giofrè, S., Iannazzo, D., Piperno, A., et al. (2011). Antiviral activity of seed extract from Citrus bergamia towards human retroviruses. BIOORGANIC & MEDICINAL CHEMISTRY, 19(6), 2084-2089 [10.1016/j.bmc.2011.01.024].

Antiviral activity of seed extract from Citrus bergamia towards human retroviruses

BALESTRIERI, EMANUELA;MACCHI, BEATRICE
2011-03-15

Abstract

The effects of an extract from Citrus bergamia (BSext) and those of two products purified from the same extract, that is, nomilin and limonin, and reference compounds, towards HTLV-1 have been reported. Moreover, they were also compared with those obtained towards HIV-1. Results showed that the efficacy of both BSext and limonin in inhibiting HTLV-1 as well as HIV-1 expression in infected cells, as evaluated by comparable quantitative assays, was close to that of the effective, reference compounds, respectively. The protective effect of BSext and of the purified products was associated with the inhibition of both HTLV-1 and HIV-1 RT activities in conceptually similar, cell-free assays. The cytotoxicity of the assayed compounds of natural origin was substantially less pronounced than that of the reference compounds, thus showing a favourable selectivity index for the novel BSext product.
15-mar-2011
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14 - FARMACOLOGIA
Settore CHIM/06 - CHIMICA ORGANICA
English
Con Impact Factor ISI
Natural products Bergamot Limonoids Antiretrovirals HIV HTLV-1 Reverse transcriptase
Balestrieri, E., Pizzimenti, F., Ferlazzo, A., Giofrè, S., Iannazzo, D., Piperno, A., et al. (2011). Antiviral activity of seed extract from Citrus bergamia towards human retroviruses. BIOORGANIC & MEDICINAL CHEMISTRY, 19(6), 2084-2089 [10.1016/j.bmc.2011.01.024].
Balestrieri, E; Pizzimenti, F; Ferlazzo, A; Giofrè, S; Iannazzo, D; Piperno, A; Romeo, R; Chiacchio, M; Mastino, A; Macchi, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/127616
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