Study Objective: Recent studies report a link between obstructive sleep apnea (OSA) syndrome, low vitamin D levels, and high parathyroid hormone (PTH) concentrations. The aim of the current study is to evaluate the effect of 7-night continuous positive airway pressure (CPAP) therapy on serum vitamin D, PTH, and calcium levels in patients with severe OSA syndrome. Methods: Patients with severe OSA were enrolled into the study and compared to control subjects. Patients with OSA underwent CPAP therapy for 7 nights and were consequently divided into responders (OSA-R, mean residual AHI < 5/h) and nonresponders (OSA-nR, mean residual AHI > 5/h). Serum vitamin D, PTH, and calcium levels were measured at baseline in patients with severe OSA (apnea-hypopnea index > 30/h) and control subjects. Patients with OSA underwent a final morning blood sample after 7-night CPAP therapy. Results: We enrolled 90 patients with OSA into the study (65 OSA-R and 25 OSA-nR) compared to 32 control subjects. At baseline, lower vitamin D and higher PTH levels were detected in the OSA group compared to controls. After 7-night CPAP therapy, male OSA-R patients showed a significant increase in vitamin D levels. Conversely, female OSA-R patients did not show the same increase in vitamin D levels. It was also observed that OSA-nR subjects did not show modifications of serum markers after nCPAP-therapy. Conclusions: The study demonstrates that short-term nCPAP treatment is able to promote the recovery of vitamin D homeostasis in male patients with OSA. The mediation of sexual hormones in regulating vitamin D is a possible explanation of the lack of recovery of vitamin D homeostasis in female patients with OSA as it often affects postmenopausal women.
|Tipologia:||Articolo su rivista|
|Citazione:||Liguori, C., Romigi, A., Izzi, F., Mercuri, N.B., Cordella, A., Tarquini, E., et al. (2015). Continuous positive airway pressure treatment increases serum vitamin D levels in male patients with obstructive sleep apnea. JOURNAL OF CLINICAL SLEEP MEDICINE, 11(6), 603-607.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||10.5664/jcsm.4766|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2015|
|Titolo:||Continuous positive airway pressure treatment increases serum vitamin D levels in male patients with obstructive sleep apnea|
|Autori interni:||MERCURI, NICOLA BIAGIO |
MARCIANI, MARIA GRAZIA
|Autori:||Liguori, C; Romigi, A; Izzi, F; Mercuri, NB; Cordella, A; Tarquini, E; Giambrone, MP; Marciani, MG; Placidi, F|
|Appare nelle tipologie:||01 - Articolo su rivista|
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