Since obesity seems to play a causal role in both obstructive sleep apnea/hypopnea syndrome (OSAHS) and type 2 diabetes, the question arises whether diet-induced weight loss is equally efficacious in type 2 diabetic patients with and without OSAHS. The present study was aimed to investigate the effect of 1 week very low calorie diet (VLCD) on oxygen desaturation index (ODI) and on glucose regulation in OSAHS versus non-OSAHS patients. Fourteen patients with type 2 diabetes mellitus and morbid obesity were enrolled. According to ODI, patients were divided into 2 groups (with and without OSAHS) and evaluated by a hyperglycemic clamp study, before and after a 7 day-VLCD. After a VLCD, a significant reduction of anthropometric parameters, in the overall group and in subgroups, was observed. M-value and acute insulin response increased significantly only in patients without obstructive sleep apnea (990.10 ± 170.19 vs. 1,205.22 ± 145.73 μmol min(-1) m(-2), p = 0.046; -1.05 ± 8.40 vs. 48.26 ± 11. 90 pmol/L, p = 0.028, respectively). The average 24-h heart rate (24-h HR) fell significantly (p = 0.05), primarily because of a decrease during daytime (p = 0.041), in the whole group. In conclusion, we observed that morbidly obese patients with type 2 diabetes and OSAHS are specifically resistant to the acute beneficial effects of VLCD on metabolic parameters. Our preliminary observation deserves further investigation to clarify the pathogenetic mechanisms involved.
|Tipologia:||Articolo su rivista|
|Citazione:||Giordani, I., Malandrucco, I., Picconi, F., Longo, S., Di Flaviani, A., Chioma, L., et al. (2013). Preliminary evidence that obese patients with obstructive sleep apnea/hypopnea syndrome are refractory to the acute beneficial metabolic effects of a very low calorie diet. ACTA DIABETOLOGICA, 50(4), 639-643.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||10.1007/s00592-013-0487-5|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2013|
|Titolo:||Preliminary evidence that obese patients with obstructive sleep apnea/hypopnea syndrome are refractory to the acute beneficial metabolic effects of a very low calorie diet|
|Autori interni:||FRONTONI, SIMONA|
|Autori:||Giordani, I; Malandrucco, I; Picconi, F; Longo, S; Di Flaviani, A; Chioma, L; Moscatelli, B; Donno, S; Frontoni, S|
|Appare nelle tipologie:||01 - Articolo su rivista|
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