Human immunodeficiency virus (HIV)-infected patients carry an increased risk of lymphomagenesis. Although the majority of HIV-related lymphomas have a B-cell phenotype, the incidence of peripheral T-cell lymphomas (PTCL), including primary cutaneous subtypes, may be up to 15-fold higher than in the general population, with anaplastic large cell lymphomas (ALCL) accounting for 18-28% of HIV-associated PTCL. In contrast to systemic ALCL, the relation between HIV infection and primary cutaneous ALCL has been relatively neglected in the literature. We report the case of a primary cutaneous ALCL occurring in a 76-year-old patient with advanced HIV infection, and showing unusually aggressive course. Neither ALK1 immunohistochemical positivity nor evidence of EBV infection were detected; staging procedures at initial presentation ruled out systemic involvement. We provide a summary of the literature regarding primary cutaneous ALCL in HIV-infected patients. We draw attention to clinicopathological features, prognostic implications and therapeutic quandaries of HIV-related primary cutaneous ALCL. Further, we propose that a significant fraction of HIV-associated cases might represent a more aggressive subset of primary cutaneous ALCL.

Saggini, A., Anemona, L., Chimenti, S., Sarmati, L., Torti, C., Di Stefani, A., et al. (2012). HIV-associated primary cutaneous anaplastic large cell lymphoma: A clinicopathological subset with more aggressive behavior? Case report and review of the literature. JOURNAL OF CUTANEOUS PATHOLOGY, 39(12), 1100-1109 [10.1111/cup.12020].

HIV-associated primary cutaneous anaplastic large cell lymphoma: A clinicopathological subset with more aggressive behavior? Case report and review of the literature

SAGGINI, ANDREA;ANEMONA, LUCIA;CHIMENTI, SERGIO;SARMATI, LOREDANA;DI STEFANI, ALESSANDRO;BIANCHI, LUCA
2012

Abstract

Human immunodeficiency virus (HIV)-infected patients carry an increased risk of lymphomagenesis. Although the majority of HIV-related lymphomas have a B-cell phenotype, the incidence of peripheral T-cell lymphomas (PTCL), including primary cutaneous subtypes, may be up to 15-fold higher than in the general population, with anaplastic large cell lymphomas (ALCL) accounting for 18-28% of HIV-associated PTCL. In contrast to systemic ALCL, the relation between HIV infection and primary cutaneous ALCL has been relatively neglected in the literature. We report the case of a primary cutaneous ALCL occurring in a 76-year-old patient with advanced HIV infection, and showing unusually aggressive course. Neither ALK1 immunohistochemical positivity nor evidence of EBV infection were detected; staging procedures at initial presentation ruled out systemic involvement. We provide a summary of the literature regarding primary cutaneous ALCL in HIV-infected patients. We draw attention to clinicopathological features, prognostic implications and therapeutic quandaries of HIV-related primary cutaneous ALCL. Further, we propose that a significant fraction of HIV-associated cases might represent a more aggressive subset of primary cutaneous ALCL.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/35 - Malattie Cutanee e Veneree
English
Aged; Antigens, CD; Fatal Outcome; HIV Infections; Homosexuality, Male; Humans; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Male; Skin Neoplasms; Tumor Markers, Biological
Saggini, A., Anemona, L., Chimenti, S., Sarmati, L., Torti, C., Di Stefani, A., et al. (2012). HIV-associated primary cutaneous anaplastic large cell lymphoma: A clinicopathological subset with more aggressive behavior? Case report and review of the literature. JOURNAL OF CUTANEOUS PATHOLOGY, 39(12), 1100-1109 [10.1111/cup.12020].
Saggini, A; Anemona, L; Chimenti, S; Sarmati, L; Torti, C; DI STEFANI, A; Bianchi, L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/124771
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