Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We investigated the association of BMP-4 gene polymorphism with osteoporosis in a cohort of 72 osteoporotic, postmenopausal women and 82 unrelated controls. We failed to detect any significant association between this genetic marker and the disease.

Semprini, S., Mango, R., Brancati, F., Dallapiccola, B., Becherini, L., Novelli, G., et al. (2000). Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women. CALCIFIED TISSUE INTERNATIONAL, 67(1), 93-4.

Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women

NOVELLI, GIUSEPPE;DE LORENZO, ANTONINO;
2000

Abstract

Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We investigated the association of BMP-4 gene polymorphism with osteoporosis in a cohort of 72 osteoporotic, postmenopausal women and 82 unrelated controls. We failed to detect any significant association between this genetic marker and the disease.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
English
Osteoporosis; Polymorphism, Genetic; Postmenopause; Female; Bone Morphogenetic Proteins; Italy; Bone Morphogenetic Protein 4; Humans
Semprini, S., Mango, R., Brancati, F., Dallapiccola, B., Becherini, L., Novelli, G., et al. (2000). Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women. CALCIFIED TISSUE INTERNATIONAL, 67(1), 93-4.
Semprini, S; Mango, R; Brancati, F; Dallapiccola, B; Becherini, L; Novelli, G; DE LORENZO, A; Brandi, M; Gennari, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/12155
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