Although most experimental data suggest that exposure to nanomaterials may be dangerous, the matter of their toxicity in humans is still unresolved. A key question is whether they may be more toxic than their bulk counterpart. To clarify this issue, we perform an in-depth analysis of size-related toxicological properties and discuss the pathogenetic pathways activated by oxidative and non-oxidative stress. In addition, new insights on the complex molecular inter-relationships arising from 'omics' are examined, in light of the information they can provide on specific intracellular events elicited by nanomaterials. Finally, we describe the mechanism of action of fibre-like nanomaterials. © 2014 Woodhead Publishing Limited. All rights reserved.
Pietroiusti, A., Magrini, A., Campagnolo, L. (2014). Mechanisms of nanomaterial toxicity. In Health and Environmental Safety of Nanomaterials: Polymer Nancomposites and Other Materials Containing Nanoparticles (pp. 28-43). Elsevier Ltd. [10.1533/9780857096678.1.28].
Mechanisms of nanomaterial toxicity
PIETROIUSTI, ANTONIO;MAGRINI, ANDREA;CAMPAGNOLO, LUISA
2014-01-01
Abstract
Although most experimental data suggest that exposure to nanomaterials may be dangerous, the matter of their toxicity in humans is still unresolved. A key question is whether they may be more toxic than their bulk counterpart. To clarify this issue, we perform an in-depth analysis of size-related toxicological properties and discuss the pathogenetic pathways activated by oxidative and non-oxidative stress. In addition, new insights on the complex molecular inter-relationships arising from 'omics' are examined, in light of the information they can provide on specific intracellular events elicited by nanomaterials. Finally, we describe the mechanism of action of fibre-like nanomaterials. © 2014 Woodhead Publishing Limited. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
