Major depressive disorder (MDD) is associated with low-grade inflammation, and it is considered a risk factor for coronary artery disease (CAD). CD40 ligand (CD40L) plays an important role in inflammation, platelet activation, and clotting system activation. We investigated soluble CD40L (sCD40L) expression in MDD and assessed whether it may represent a molecular mechanism that links inflammation and a prothrombotic state and whether this condition may be modified by selective serotonin reuptake inhibitor (SSRI) therapy.

Leo, R., DI LORENZO, G., Tesauro, M., Razzini, C., Forleo, G., Chiricolo, G., et al. (2006). Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. JOURNAL OF CLINICAL PSYCHIATRY, 67(11), 1760-1766.

Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy

LEO, ROBERTO;DI LORENZO, GIORGIO;TESAURO, MANFREDI;RAZZINI, CINZIA;CHIRICOLO, GAETANO;ZANASI, MARCO;TROISI, ALFONSO;SIRACUSANO, ALBERTO;LAURO, RENATO;ROMEO, FRANCESCO
2006

Abstract

Major depressive disorder (MDD) is associated with low-grade inflammation, and it is considered a risk factor for coronary artery disease (CAD). CD40 ligand (CD40L) plays an important role in inflammation, platelet activation, and clotting system activation. We investigated soluble CD40L (sCD40L) expression in MDD and assessed whether it may represent a molecular mechanism that links inflammation and a prothrombotic state and whether this condition may be modified by selective serotonin reuptake inhibitor (SSRI) therapy.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - Medicina Interna
English
Adult; Biological Markers; CD40 Ligand; Citalopram; Depressive Disorder, Major; Factor VIIa; Female; Humans; Inflammation; Interleukin-1beta; Male; P-Selectin; Pilot Projects; Serotonin Uptake Inhibitors; Sertraline; Tumor Necrosis Factor-alpha; Up-Regulation
Leo, R., DI LORENZO, G., Tesauro, M., Razzini, C., Forleo, G., Chiricolo, G., et al. (2006). Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. JOURNAL OF CLINICAL PSYCHIATRY, 67(11), 1760-1766.
Leo, R; DI LORENZO, G; Tesauro, M; Razzini, C; Forleo, G; Chiricolo, G; Cola, C; Zanasi, M; Troisi, A; Siracusano, A; Lauro, R; Romeo, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/121168
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