Erythrocyte glutathione transferase (e-GST) is a detoxifying enzyme hyper-expressed in nephropathic patients and used recently as a biomarker for blood toxicity. Systemic sclerosis (SSc) is characterized by endothelial dysfunction and fibrosis of the skin and internal organs. Renal involvement is frequent in SSc patients. Here we show that e-GST is hyper-expressed in SSc patients (n = 102) and correlates (R(2) = 0.49, P < 0.0001) with the Medsger DSS and DAI Valentini indices that quantify the severity and activity of this disease. Interestingly, e-GST does not correlate with the impairment of kidney or other specific organs taken separately. e-GST hyper-expression seems to be linked to the presence of a factor (i.e., toxin) that triggers the autoimmune disease, and not to the damage of specific organs or to oxidative stress. e-GST may be proposed as an innovative non-antibody biomarker for SSc useful to check the progress of this disease and the efficiency of new therapeutic strategies.

Fabrini, R., Rosato, N., Gigante, G., Bocedi, A., Cianci, C., Barbano, B., et al. (2013). Erythrocyte glutathione transferase: A non-antibody biomarker for systemic sclerosis, which correlates with severity and activity of the disease. CELL DEATH & DISEASE, 4(7), e736 [10.1038/cddis.2013.255].

Erythrocyte glutathione transferase: A non-antibody biomarker for systemic sclerosis, which correlates with severity and activity of the disease

FABRINI, RAFFAELE;ROSATO, NICOLA;GIGANTE, GAETANO;Bocedi, A;CIANCI, CORRADO;RICCI, FRANCESCO;RICCI, GIORGIO;Grosso, Ed
2013-01-01

Abstract

Erythrocyte glutathione transferase (e-GST) is a detoxifying enzyme hyper-expressed in nephropathic patients and used recently as a biomarker for blood toxicity. Systemic sclerosis (SSc) is characterized by endothelial dysfunction and fibrosis of the skin and internal organs. Renal involvement is frequent in SSc patients. Here we show that e-GST is hyper-expressed in SSc patients (n = 102) and correlates (R(2) = 0.49, P < 0.0001) with the Medsger DSS and DAI Valentini indices that quantify the severity and activity of this disease. Interestingly, e-GST does not correlate with the impairment of kidney or other specific organs taken separately. e-GST hyper-expression seems to be linked to the presence of a factor (i.e., toxin) that triggers the autoimmune disease, and not to the damage of specific organs or to oxidative stress. e-GST may be proposed as an innovative non-antibody biomarker for SSc useful to check the progress of this disease and the efficiency of new therapeutic strategies.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10
English
Biological Markers; Erythrocytes; Female; Glutathione Transferase; Humans; Male; Middle Aged; Scleroderma, Systemic
Fabrini, R., Rosato, N., Gigante, G., Bocedi, A., Cianci, C., Barbano, B., et al. (2013). Erythrocyte glutathione transferase: A non-antibody biomarker for systemic sclerosis, which correlates with severity and activity of the disease. CELL DEATH & DISEASE, 4(7), e736 [10.1038/cddis.2013.255].
Fabrini, R; Rosato, N; Gigante, G; Bocedi, A; Cianci, C; Barbano, B; Grosso, E; Ricci, F; Zingaretti, V; Salsano, F; Ricci, G; DEL GROSSO, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/120024
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