Introduction: Psoriasis is a chronic inflammatory skin disorder determined by the activation of several immune cells and resident tissue cells. Various cytokines mediate inflammatory signals, including IL-23, which is an important factor involved in the differentiation of T helper (Th17) cells. Areas covered: Increasing evidence suggests that IL-23 is a central cytokine to the pathogenesis of psoriasis. An overview on both experimental and human data will be reported in order to support the hypothesis of a key pathogenic role of IL-23/Th17 axis. Expert opinion: Targeting IL-23 might be a more selective, valid and effective therapeutic approach, which, potentially, may show important advantages in terms of long-term efficacy and safety in the treatment of psoriasis. © 2014 Informa UK, Ltd.
Chiricozzi, A., Saraceno, R., Chimenti, M.s., Guttman Yassky, E., Krueger, J. (2014). Role of IL-23 in the pathogenesis of psoriasis: A novel potential therapeutic target?. EXPERT OPINION ON THERAPEUTIC TARGETS, 18(5), 513-525 [10.1517/14728222.2014.889686].
Role of IL-23 in the pathogenesis of psoriasis: A novel potential therapeutic target?
CHIRICOZZI, ANDREA;SARACENO, ROSITA;CHIMENTI, MARIA SOLE;
2014-01-01
Abstract
Introduction: Psoriasis is a chronic inflammatory skin disorder determined by the activation of several immune cells and resident tissue cells. Various cytokines mediate inflammatory signals, including IL-23, which is an important factor involved in the differentiation of T helper (Th17) cells. Areas covered: Increasing evidence suggests that IL-23 is a central cytokine to the pathogenesis of psoriasis. An overview on both experimental and human data will be reported in order to support the hypothesis of a key pathogenic role of IL-23/Th17 axis. Expert opinion: Targeting IL-23 might be a more selective, valid and effective therapeutic approach, which, potentially, may show important advantages in terms of long-term efficacy and safety in the treatment of psoriasis. © 2014 Informa UK, Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
