Systemic vasculitides are a group of uncommon diseases characterized by blood vessel inflammation. The complement system is involved in the pathogenesis and clinical manifestations of several autoimmune diseases, including systemic vasculitides. This enzymatic system is a component of the innate immune system. Its main function was initially believed to be limited to the recognition and elimination of pathogens, but research in recent years has demonstrated the important role that complement proteins play in modulating adaptive immunity and in bridging innate and adaptive responses. Its activation is also critical for the development of T cell immunity and natural antibodies as well as for the regulation of autoreactive B cells. In systemic vasculitides, particularly small-medium vessel vasculitides, the complement system has been shown to contribute to the development of inflammatory damage. In view of these crucial functions, the complement system represents an attractive therapeutic target for a wide range of diseases, including vasculitic disorders.

Ballanti, E., Chimenti, M.s., Perricone, R. (2015). Small-medium vessel vasculitides: Is the complement system a potential forgotten target?. ISRAEL MEDICAL ASSOCIATION JOURNAL, 17(2), 85-92.

Small-medium vessel vasculitides: Is the complement system a potential forgotten target?

BALLANTI, ELEONORA;CHIMENTI, MARIA SOLE;PERRICONE, ROBERTO
2015-01-01

Abstract

Systemic vasculitides are a group of uncommon diseases characterized by blood vessel inflammation. The complement system is involved in the pathogenesis and clinical manifestations of several autoimmune diseases, including systemic vasculitides. This enzymatic system is a component of the innate immune system. Its main function was initially believed to be limited to the recognition and elimination of pathogens, but research in recent years has demonstrated the important role that complement proteins play in modulating adaptive immunity and in bridging innate and adaptive responses. Its activation is also critical for the development of T cell immunity and natural antibodies as well as for the regulation of autoreactive B cells. In systemic vasculitides, particularly small-medium vessel vasculitides, the complement system has been shown to contribute to the development of inflammatory damage. In view of these crucial functions, the complement system represents an attractive therapeutic target for a wide range of diseases, including vasculitic disorders.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
English
Anti-complement therapy; Complement system; Vasculitides; Medicine (all)
http://www.ima.org.il/FilesUpload/IMAJ/0/107/53797.pdf
Ballanti, E., Chimenti, M.s., Perricone, R. (2015). Small-medium vessel vasculitides: Is the complement system a potential forgotten target?. ISRAEL MEDICAL ASSOCIATION JOURNAL, 17(2), 85-92.
Ballanti, E; Chimenti, Ms; Perricone, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/119589
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