Evidence from the literature suggests that autoimmune processes may drive features of psoriatic arthritis (PsA). Such hypothesis is supported by the evidence that class I major histocompatibility complex (MHC) genes are associated with susceptibility to develop PsA and auto-reactive cells, such as CD8 T cells, T helper (h) 17 and plasma cells, have been demonstrated in PsA. However, no autoantigens have ever been demonstrated in PsA. The presence of a new autoantibody system, anti-carbamylated protein (anti-Carp) antibodies, has been identified in rheumatoid arthritis (RA) patients. These autoantibodies have been associated with a worse disease progression independent of anti-citrulline antibodies (ACPA). In PsA, anti-CarP antibodies have not been evaluated yet. We aimed at analyzing, for the first time, the anti-CarP antibodies in sera of patients with active PsA who were negative for ACPA in order to explore both their presence and their relationship with disease activity. A total of 70 individuals, 30 patients with diagnosis of PsA (according to CASPAR criteria) and 40 healthy controls (HC) were enrolled. We found significantly increased levels of anti-CarP antibodies in PsA patients compared with HC (P < 0.0001). Our findings indicate that anti-CarP antibodies are detectable with high specificity and sensibility in PsA patients suggesting an autoimmune background of PsA. Anti-CarP antibodies can be useful in improving the diagnosis of PsA and are correlated with disease activity. (C) 2015 Published by Elsevier B.V.

Chimenti, M.s., Triggianese, P., Nuccetelli, M., Terracciano, C., Crisanti, A., Guarino, M.d., et al. (2015). Auto-reactions, autoimmunity and psoriatic arthritis. AUTOIMMUNITY REVIEWS, 14(12), 1142-1146 [10.1016/j.autrev.2015.08.003].

Auto-reactions, autoimmunity and psoriatic arthritis

CHIMENTI, MARIA SOLE;Triggianese, P;GUARINO, MARIA DOMENICA;BERNARDINI, SERGIO;PERRICONE, ROBERTO
2015

Abstract

Evidence from the literature suggests that autoimmune processes may drive features of psoriatic arthritis (PsA). Such hypothesis is supported by the evidence that class I major histocompatibility complex (MHC) genes are associated with susceptibility to develop PsA and auto-reactive cells, such as CD8 T cells, T helper (h) 17 and plasma cells, have been demonstrated in PsA. However, no autoantigens have ever been demonstrated in PsA. The presence of a new autoantibody system, anti-carbamylated protein (anti-Carp) antibodies, has been identified in rheumatoid arthritis (RA) patients. These autoantibodies have been associated with a worse disease progression independent of anti-citrulline antibodies (ACPA). In PsA, anti-CarP antibodies have not been evaluated yet. We aimed at analyzing, for the first time, the anti-CarP antibodies in sera of patients with active PsA who were negative for ACPA in order to explore both their presence and their relationship with disease activity. A total of 70 individuals, 30 patients with diagnosis of PsA (according to CASPAR criteria) and 40 healthy controls (HC) were enrolled. We found significantly increased levels of anti-CarP antibodies in PsA patients compared with HC (P < 0.0001). Our findings indicate that anti-CarP antibodies are detectable with high specificity and sensibility in PsA patients suggesting an autoimmune background of PsA. Anti-CarP antibodies can be useful in improving the diagnosis of PsA and are correlated with disease activity. (C) 2015 Published by Elsevier B.V.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/16 - Reumatologia
English
Con Impact Factor ISI
Anti-carbamylated protein antibodies; Auto-reactions; Autoimmunity; Psoriatic arthritis; Animals; Arthritis, Psoriatic; Autoantibodies; Autoantigens; Carbamyl Phosphate; Citrulline; Humans; Autoimmunity
Chimenti, M.s., Triggianese, P., Nuccetelli, M., Terracciano, C., Crisanti, A., Guarino, M.d., et al. (2015). Auto-reactions, autoimmunity and psoriatic arthritis. AUTOIMMUNITY REVIEWS, 14(12), 1142-1146 [10.1016/j.autrev.2015.08.003].
Chimenti, Ms; Triggianese, P; Nuccetelli, M; Terracciano, C; Crisanti, A; Guarino, Md; Bernardini, S; Perricone, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/119539
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