Diabetic foot (DF) is a common complication of diabetes and the first cause of hospital admission in diabetic patients. In recent years several guidelines have been proposed to reinforce the the management of DF with a notable increase in diabetes knowledge and an overall reduction of amputations. Significant improvements have been reached in the treatment of diabetic foot ulcers (DFUs) and nowadays clinicians have several advanced medications to apply for the best local therapy. Among these, negative pressure wound therapy (NPWT) is a useful adjunct in the management of chronic and complex wounds to promote healing and wound bed preparation for surgical procedures such as skin grafts and flap surgery. NPWT has shown remarkable results although its mechanisms of action are not completely understood. In this paper, we offer a complete overview of this medication and its implication in the clinical setting. We have examined literature related to NPWT concerning human, animal and in vitro studies, and we have summarized why, when and how we can use NPWT to treat DFUs. Further we have associated our clinical experience to scientific evidence in the field of diabetic foot to identify a defined strategy that could guide clinician in the use of NPWT approaching to DFUs.

Meloni, M., Izzo, V., Vainieri, E., Giurato, L., Ruotolo, V., Uccioli, L. (2015). Management of negative pressure wound therapy in the treatment of diabetic foot ulcers. WORLD JOURNAL OF ORTHOPEDICS, 6(4), 387-393 [10.5312/wjo.v6.i4.387].

Management of negative pressure wound therapy in the treatment of diabetic foot ulcers

GIURATO, LAURA;UCCIOLI, LUIGI
2015-01-01

Abstract

Diabetic foot (DF) is a common complication of diabetes and the first cause of hospital admission in diabetic patients. In recent years several guidelines have been proposed to reinforce the the management of DF with a notable increase in diabetes knowledge and an overall reduction of amputations. Significant improvements have been reached in the treatment of diabetic foot ulcers (DFUs) and nowadays clinicians have several advanced medications to apply for the best local therapy. Among these, negative pressure wound therapy (NPWT) is a useful adjunct in the management of chronic and complex wounds to promote healing and wound bed preparation for surgical procedures such as skin grafts and flap surgery. NPWT has shown remarkable results although its mechanisms of action are not completely understood. In this paper, we offer a complete overview of this medication and its implication in the clinical setting. We have examined literature related to NPWT concerning human, animal and in vitro studies, and we have summarized why, when and how we can use NPWT to treat DFUs. Further we have associated our clinical experience to scientific evidence in the field of diabetic foot to identify a defined strategy that could guide clinician in the use of NPWT approaching to DFUs.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - ENDOCRINOLOGIA
English
Con Impact Factor ISI
Advanced medication; Diabetes; Diabetic foot; Negative pressure wound therapy; Wound healing
Meloni, M., Izzo, V., Vainieri, E., Giurato, L., Ruotolo, V., Uccioli, L. (2015). Management of negative pressure wound therapy in the treatment of diabetic foot ulcers. WORLD JOURNAL OF ORTHOPEDICS, 6(4), 387-393 [10.5312/wjo.v6.i4.387].
Meloni, M; Izzo, V; Vainieri, E; Giurato, L; Ruotolo, V; Uccioli, L
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/119087
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