To investigate the factors affecting (18)F FDOPA uptake in patients with primary brain tumors (PBT) after treatment. MATERIALS AND METHODS: 97 patients with PBT (6 were grade I, 40 were grade II, 29 were grade III and 22 were grade IV) underwent (18)F FDOPA positron emission tomography/computed tomography (PET/CT) after treatment. Intervals from surgery, chemotherapy (CHT) and radiotherapy (RT) were 41.48 (±42.27), 16.04 (±29.08) and 28.62 (±34.49) months respectively. RESULTS: (18)F FDOPA uptake in the site of recurrence was not related to the interval from surgery and CHT while a significant relationship has been found with the interval from RT and tumor grade. CONCLUSIONS: The results of our study show that the interval from RT and the grade of PBT should be considered carefully when evaluating brain PET/CT scans since these factors could directly affect (18)F FDOPA uptake. Copyright © 2015 Elsevier Inc. All rights reserved.
Chiaravalloti, A., Fiorentini, A., Villani, V., Carapella, C., Pace, A., Di Pietro, B., et al. (2015). Factors affecting 18F FDOPA standardized uptake value in patients with primary brain tumors after treatment. NUCLEAR MEDICINE AND BIOLOGY, 42(4), 355-359 [10.1016/j.nucmedbio.2015.01.002].
Factors affecting 18F FDOPA standardized uptake value in patients with primary brain tumors after treatment
CHIARAVALLOTI, AGOSTINO;FIORENTINI, ALESSIA;FLORIS, ROBERTO;SCHILLACI, ORAZIO
2015-01-01
Abstract
To investigate the factors affecting (18)F FDOPA uptake in patients with primary brain tumors (PBT) after treatment. MATERIALS AND METHODS: 97 patients with PBT (6 were grade I, 40 were grade II, 29 were grade III and 22 were grade IV) underwent (18)F FDOPA positron emission tomography/computed tomography (PET/CT) after treatment. Intervals from surgery, chemotherapy (CHT) and radiotherapy (RT) were 41.48 (±42.27), 16.04 (±29.08) and 28.62 (±34.49) months respectively. RESULTS: (18)F FDOPA uptake in the site of recurrence was not related to the interval from surgery and CHT while a significant relationship has been found with the interval from RT and tumor grade. CONCLUSIONS: The results of our study show that the interval from RT and the grade of PBT should be considered carefully when evaluating brain PET/CT scans since these factors could directly affect (18)F FDOPA uptake. Copyright © 2015 Elsevier Inc. All rights reserved.| File | Dimensione | Formato | |
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