TTo investigate the diagnostic performance of early acquisition compared to late imaging for the detection of local recurrence of prostate cancer by means of 18F-FCH PET/CT. Materials and methods 99 patients with radical prostatectomy (mean PSA 3.9 ± 5.03) were subjected to early dynamic PET/CT acquisition of the pelvis and a whole body PET/CT in the same exam session. None of the patients examined was subjected to radiotherapy for local or distant recurrence. All the subjects were taken off hormonal therapy. Results 58 subjects did not show local recurrence in both early and late acquisition, 22 were positive in both modalities, 10 showed a positive early and a negative late acquisition while 9 showed a negative early and a positive late acquisition (Cohen’s k = 0.558). When the results of imaging modalities were considered separately, sensitivity, specificity, positive predictive value and negative predictive value resulted: 78.9, 96.7, 93.8 and 88.1 % for early acquisition and 73.7, 95.1, 90.3 and 85.3 % for late acquisition, respectively. When the results of early and late acquisition were considered together, results were 97.4, 93.4, 90.2 and 98.3 %, respectively. Conclusions The combination of early acquisition with late acquisition lead to an increase of the diagnostic accuracy of 18F-FCH PET/CT for the diagnosis of local recurrence in prostate cancer.

Di Biagio, D., Chiaravalloti, A., Tavolozza, M., Abbatiello, P., Schillaci, O. (2015). Detection of local recurrence of prostate cancer after radical prostatectomy: Is there a role for early <sup>18</sup>F-FCH PET/CT?. ANNALS OF NUCLEAR MEDICINE [10.1007/s12149-015-1015-1].

Detection of local recurrence of prostate cancer after radical prostatectomy: Is there a role for early 18F-FCH PET/CT?

CHIARAVALLOTI, AGOSTINO;TAVOLOZZA, MARIO;SCHILLACI, ORAZIO
2015-08-11

Abstract

TTo investigate the diagnostic performance of early acquisition compared to late imaging for the detection of local recurrence of prostate cancer by means of 18F-FCH PET/CT. Materials and methods 99 patients with radical prostatectomy (mean PSA 3.9 ± 5.03) were subjected to early dynamic PET/CT acquisition of the pelvis and a whole body PET/CT in the same exam session. None of the patients examined was subjected to radiotherapy for local or distant recurrence. All the subjects were taken off hormonal therapy. Results 58 subjects did not show local recurrence in both early and late acquisition, 22 were positive in both modalities, 10 showed a positive early and a negative late acquisition while 9 showed a negative early and a positive late acquisition (Cohen’s k = 0.558). When the results of imaging modalities were considered separately, sensitivity, specificity, positive predictive value and negative predictive value resulted: 78.9, 96.7, 93.8 and 88.1 % for early acquisition and 73.7, 95.1, 90.3 and 85.3 % for late acquisition, respectively. When the results of early and late acquisition were considered together, results were 97.4, 93.4, 90.2 and 98.3 %, respectively. Conclusions The combination of early acquisition with late acquisition lead to an increase of the diagnostic accuracy of 18F-FCH PET/CT for the diagnosis of local recurrence in prostate cancer.
11-ago-2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
18F-FCH PET/CT Local recurrence Early acquisition Prostate cancer PSA
http://link.springer.com/article/10.1007%2Fs12149-015-1015-1
Di Biagio, D., Chiaravalloti, A., Tavolozza, M., Abbatiello, P., Schillaci, O. (2015). Detection of local recurrence of prostate cancer after radical prostatectomy: Is there a role for early <sup>18</sup>F-FCH PET/CT?. ANNALS OF NUCLEAR MEDICINE [10.1007/s12149-015-1015-1].
Di Biagio, D; Chiaravalloti, A; Tavolozza, M; Abbatiello, P; Schillaci, O
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/118658
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