The humanized CD20 mono- clonal antibody, rituximab, has significant anti-tumor activity in patients with B-cell non-Hodgkin's lymphoma and induces depletion of B-cells in vivo. It was the objective of this study to define the contribution of the different mechanisms of action of rituximab on primary normal and malignant B-cells.

Voso, M.t., Pantel, G., Rutella, S., Weis, M., D'Alò, F., Urbano, R., et al. (2002). Rituximab reduces the number of peripheral blood B-cells in vitro mainly by effector cell-mediated mechanisms. HAEMATOLOGICA, 87(9), 918-925.

Rituximab reduces the number of peripheral blood B-cells in vitro mainly by effector cell-mediated mechanisms

VOSO, MARIA TERESA;
2002-09-01

Abstract

The humanized CD20 mono- clonal antibody, rituximab, has significant anti-tumor activity in patients with B-cell non-Hodgkin's lymphoma and induces depletion of B-cells in vivo. It was the objective of this study to define the contribution of the different mechanisms of action of rituximab on primary normal and malignant B-cells.
set-2002
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD14; Antigens, CD3; Antigens, CD56; B-Lymphocytes; Cell Count; Cell Division; Cell Line, Tumor; Cells, Cultured; Humans; Leukemia, B-Cell
Voso, M.t., Pantel, G., Rutella, S., Weis, M., D'Alò, F., Urbano, R., et al. (2002). Rituximab reduces the number of peripheral blood B-cells in vitro mainly by effector cell-mediated mechanisms. HAEMATOLOGICA, 87(9), 918-925.
Voso, Mt; Pantel, G; Rutella, S; Weis, M; D'Alò, F; Urbano, R; Leone, G; Haas, R; Hohaus, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/118465
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