Telomerase is the enzyme that stabilizes and elongates the telomeric ends of chromosomes. It is expressed in germline and malignant cells and absent in most human somatic cells. The selective expression of telomerase has thus been proposed to be a basis for the immortality of germline and malignant cells. Recently, telomerase activity has been observed in human bone marrow (BM) and peripheral blood (PB) samples. The objective of our study was to further characterize the telomerase-expressing population in BM and PB.

Hohaus, S., Voso, M.t., Orta La Barbera, E., Cavallo, S., Bellacosa, A., Rutella, S., et al. (1997). Telomerase activity in human hematopoietic progenitor cells. HAEMATOLOGICA, 82(3), 262-268.

Telomerase activity in human hematopoietic progenitor cells

VOSO, MARIA TERESA;
1997-01-01

Abstract

Telomerase is the enzyme that stabilizes and elongates the telomeric ends of chromosomes. It is expressed in germline and malignant cells and absent in most human somatic cells. The selective expression of telomerase has thus been proposed to be a basis for the immortality of germline and malignant cells. Recently, telomerase activity has been observed in human bone marrow (BM) and peripheral blood (PB) samples. The objective of our study was to further characterize the telomerase-expressing population in BM and PB.
1997
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Antigens, CD34; Blood Cells; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Colony-Forming Units Assay; Enzyme Induction; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Neoplastic Stem Cells; Polymerase Chain Reaction; Telomerase; Tumor Cells, Cultured
Hohaus, S., Voso, M.t., Orta La Barbera, E., Cavallo, S., Bellacosa, A., Rutella, S., et al. (1997). Telomerase activity in human hematopoietic progenitor cells. HAEMATOLOGICA, 82(3), 262-268.
Hohaus, S; Voso, Mt; Orta La Barbera, E; Cavallo, S; Bellacosa, A; Rutella, S; Rumi, C; Genuardi, M; Neri, G; Leone, G
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/118449
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