Epigenetic changes play a role and cooperate with genetic alterations in the pathogenesis of myelodysplastic syndromes (MDS). We conducted a phase II multicenter study on the combination of the DNA-methyltransferase inhibitor 5-azacytidine (5-AZA) and the histone deacetylase inhibitor valproic acid (VPA) in patients with higher risk MDS.

Voso, M.t., Santini, V., Finelli, C., Musto, P., Pogliani, E., Angelucci, E., et al. (2009). Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes. CLINICAL CANCER RESEARCH, 15(15), 5002-5007 [10.1158/1078-0432.CCR-09-0494].

Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes

VOSO, MARIA TERESA;BUCCISANO, FRANCESCO;AMADORI, SERGIO;
2009-08-01

Abstract

Epigenetic changes play a role and cooperate with genetic alterations in the pathogenesis of myelodysplastic syndromes (MDS). We conducted a phase II multicenter study on the combination of the DNA-methyltransferase inhibitor 5-azacytidine (5-AZA) and the histone deacetylase inhibitor valproic acid (VPA) in patients with higher risk MDS.
1-ago-2009
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Azacitidine; Cytochrome P-450 CYP2C19; DNA Methylation; Drug Therapy, Combination; Enzyme Inhibitors; Epigenesis, Genetic; Female; Humans; Male; Methyltransferases; Middle Aged; Myelodysplastic Syndromes; Polymorphism, Single Nucleotide; Prognosis; Valproic Acid; Histone Deacetylase Inhibitors
Voso, M.t., Santini, V., Finelli, C., Musto, P., Pogliani, E., Angelucci, E., et al. (2009). Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes. CLINICAL CANCER RESEARCH, 15(15), 5002-5007 [10.1158/1078-0432.CCR-09-0494].
Voso, Mt; Santini, V; Finelli, C; Musto, P; Pogliani, E; Angelucci, E; Fioritoni, G; Alimena, G; Maurillo, L; Cortelezzi, A; Buccisano, F; Gobbi, M; Borin, L; Di Tucci, A; Zini, G; Petti, M; Martinelli, G; Fabiani, E; Fazi, P; Vignetti, M; Piciocchi, A; Liso, V; Amadori, S; Leone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/118302
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