Glutathione S-transferase P1 (GSTP1) is a member of the GST enzyme superfamily that is important for the detoxification of several cytotoxic drugs and their by-products. A single nucleotide polymorphism results in the substitution of isoleucine (Ile) to valine (Val) at codon 105, causing a metabolically less active variant of the enzyme. We assessed the impact of the GSTP1 codon 105 genotype on treatment outcome in patients with Hodgkin's lymphoma.

Hohaus, S., Di Ruscio, A., Di Febo, A., Massini, G., D'Alo', F., Guidi, F., et al. (2005). Glutathione S-transferase P1 genotype and prognosis in Hodgkin's lymphoma. CLINICAL CANCER RESEARCH, 11(6), 2175-2179 [10.1158/1078-0432.CCR-04-1250].

Glutathione S-transferase P1 genotype and prognosis in Hodgkin's lymphoma

VOSO, MARIA TERESA;
2005-03-15

Abstract

Glutathione S-transferase P1 (GSTP1) is a member of the GST enzyme superfamily that is important for the detoxification of several cytotoxic drugs and their by-products. A single nucleotide polymorphism results in the substitution of isoleucine (Ile) to valine (Val) at codon 105, causing a metabolically less active variant of the enzyme. We assessed the impact of the GSTP1 codon 105 genotype on treatment outcome in patients with Hodgkin's lymphoma.
15-mar-2005
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Adolescent; Adult; Aged; Disease-Free Survival; Female; Genetic Predisposition to Disease; Genotype; Glutathione S-Transferase pi; Glutathione Transferase; Hodgkin Disease; Humans; Isoenzymes; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prognosis; Survival Rate; Treatment Outcome
Hohaus, S., Di Ruscio, A., Di Febo, A., Massini, G., D'Alo', F., Guidi, F., et al. (2005). Glutathione S-transferase P1 genotype and prognosis in Hodgkin's lymphoma. CLINICAL CANCER RESEARCH, 11(6), 2175-2179 [10.1158/1078-0432.CCR-04-1250].
Hohaus, S; Di Ruscio, A; Di Febo, A; Massini, G; D'Alo', F; Guidi, F; Mansueto, G; Voso, Mt; Leone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/118255
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