Adenosine deaminase acting on RNA1 (ADAR1) was previously reported to affect HIV-1 replication. We report data showing that ADAR1 interacts with the HIV-1 p55 Gag protein, the major structural protein of the immature virus capsid. Furthermore, we found that the endogenous ADAR1 is incorporated into virions purified from the supernatant of primary HIV-1-infected CD4(+) T lymphocytes. Additional experiments demonstrated that the expression of the p55 Gag protein is sufficient for ADAR1 incorporation into virus-like particles (VLPs). Overall, our data originally support the evidence that ADAR1 can be part of the cell protein array uploaded in HIV-1 particles.
Orecchini, E., Federico, M., Doria, M., Arenaccio, C., Giuliani, E., Ciafre', S.A., et al. (2015). The ADAR1 editing enzyme is encapsidated into HIV-1 virions. VIROLOGY, 485, 475-480.
Tipologia: | Articolo su rivista |
Citazione: | Orecchini, E., Federico, M., Doria, M., Arenaccio, C., Giuliani, E., Ciafre', S.A., et al. (2015). The ADAR1 editing enzyme is encapsidated into HIV-1 virions. VIROLOGY, 485, 475-480. |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/13 |
Revisione (peer review): | Esperti anonimi |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.virol.2015.07.027 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2015 |
Titolo: | The ADAR1 editing enzyme is encapsidated into HIV-1 virions |
Autori: | |
Autori: | Orecchini, E; Federico, M; Doria, M; Arenaccio, C; Giuliani, E; Ciafre', SA; Michienzi, A |
Appare nelle tipologie: | 01 - Articolo su rivista |
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