We report two cases of invasive zygomycoses occurring in severely immunocompromised patients with haematological malignancies that were successfully treated with liposomal amphotericin B and surgical debridement, followed by oral administration of posaconazole. These cases demonstrated that an early instituted, aggressive and combined therapeutic approach results in a recovery from invasive fungal infection, without any relapse of infection, thanks to secondary prophylaxis using posaconazole.

Valentini, C., Candoni, A., Fianchi, L., Posteraro, B., Simeone, E., Costa, F., et al. (2010). Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies. MYCOSES, 53(1), 89-92 [10.1111/j.1439-0507.2008.01672.x].

Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies

VOSO, MARIA TERESA;
2010-01-01

Abstract

We report two cases of invasive zygomycoses occurring in severely immunocompromised patients with haematological malignancies that were successfully treated with liposomal amphotericin B and surgical debridement, followed by oral administration of posaconazole. These cases demonstrated that an early instituted, aggressive and combined therapeutic approach results in a recovery from invasive fungal infection, without any relapse of infection, thanks to secondary prophylaxis using posaconazole.
gen-2010
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Aged; Amphotericin B; Antifungal Agents; Hematologic Neoplasms; Humans; Immunocompromised Host; Male; Middle Aged; Treatment Outcome; Triazoles; Zygomycosis
Valentini, C., Candoni, A., Fianchi, L., Posteraro, B., Simeone, E., Costa, F., et al. (2010). Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies. MYCOSES, 53(1), 89-92 [10.1111/j.1439-0507.2008.01672.x].
Valentini, C; Candoni, A; Fianchi, L; Posteraro, B; Simeone, E; Costa, F; Sanguinetti, M; Voso, Mt; Caira, M; Fanin, R; Pagano, L
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/118085
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