The Drosophila dishevelled gene (dsh) encodes a secreted glycoprotein, which regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. We have isolated and characterized cDNA clones from two different human dsh-homologous genes, designated as DVL-1 and DVL-3. DVL-1 and DVL-3 putative protein products show 64% amino acid identity. The DVL-1 product is 50% identical to dsh and 92% to a murine dsh homologue (Dvl-1). Both human DVL genes are widely expressed in fetal and adult tissues, including brain, lung, kidney, skeletal muscle and heart. DVL-1 locus maps to chromosome 1p36 and DVL-3 to chromosome 3q27. DVL-1 locus on chromosome 1 corresponds to the murine syntenic region where Dvl-1 is located. DVL-1 and DVL-3 are members of a human dsh-like gene family, which is probably involved in human development. Although the precise role of these genes in embryogenesis is only conjectural at present, the structural and evolutionary characteristics suggest that mutations at their loci may be involved in neural and heart developmental defects.

Pizzuti, A., Amati, F., Calabrese, G., Mari, A., Colosimo, A., Silani, V., et al. (1996). cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. HUMAN MOLECULAR GENETICS, 5(7), 953-958.

cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene

AMATI, FRANCESCA;NOVELLI, GIUSEPPE;
1996-07-01

Abstract

The Drosophila dishevelled gene (dsh) encodes a secreted glycoprotein, which regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. We have isolated and characterized cDNA clones from two different human dsh-homologous genes, designated as DVL-1 and DVL-3. DVL-1 and DVL-3 putative protein products show 64% amino acid identity. The DVL-1 product is 50% identical to dsh and 92% to a murine dsh homologue (Dvl-1). Both human DVL genes are widely expressed in fetal and adult tissues, including brain, lung, kidney, skeletal muscle and heart. DVL-1 locus maps to chromosome 1p36 and DVL-3 to chromosome 3q27. DVL-1 locus on chromosome 1 corresponds to the murine syntenic region where Dvl-1 is located. DVL-1 and DVL-3 are members of a human dsh-like gene family, which is probably involved in human development. Although the precise role of these genes in embryogenesis is only conjectural at present, the structural and evolutionary characteristics suggest that mutations at their loci may be involved in neural and heart developmental defects.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03 - Genetica Medica
English
Con Impact Factor ISI
Animals; Sequence Homology, Nucleic Acid; Humans; Organ Specificity; Amino Acid Sequence; Sequence Analysis, DNA; Chromosome Mapping; Cloning, Molecular; RNA, Messenger; Chromosomes, Human, Pair 1; DNA, Complementary; Chromosomes, Human, Pair 3; Phosphoproteins; Adaptor Proteins, Signal Transducing; Adult; Molecular Sequence Data; Proteins; Sequence Homology, Amino Acid; Drosophila; Gene Expression Regulation, Developmental
http://hmg.oxfordjournals.org/content/5/7/953.long
Pizzuti, A., Amati, F., Calabrese, G., Mari, A., Colosimo, A., Silani, V., et al. (1996). cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. HUMAN MOLECULAR GENETICS, 5(7), 953-958.
Pizzuti, A; Amati, F; Calabrese, G; Mari, A; Colosimo, A; Silani, V; Giardino, L; Ratti, A; Penso, D; Calzà, L; Palka, G; Scarlato, G; Novelli, G; Dallapiccola, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/117862
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