We consider a simplified 1-dimensional PDE-model describing the effect of contact inhibition in growth processes of normal and abnormal cells. Varying the value of a significant parameter, numerical tests suggest two different types of contact inhibition between the cell populations: the two populations move with constant velocity and exhibit spatial segregation, or they stop to move and regions of coexistence are formed. In order to understand the different mechanisms, we prove that there exists a segregated traveling wave solution for a unique wave speed, and we present numerical results on the "stability" of the segregated waves. We conjecture the existence of a non-segregated standing wave for certain parameter values.

Bertsch, M., Mimura, M., Wakasa, T. (2013). Modeling contact inhibition of growth: traveling waves. NETWORKS AND HETEROGENEOUS MEDIA, 8(1), 131-147 [10.3934/nhm.2013.8.131].

Modeling contact inhibition of growth: traveling waves

BERTSCH, MICHIEL;
2013-01-01

Abstract

We consider a simplified 1-dimensional PDE-model describing the effect of contact inhibition in growth processes of normal and abnormal cells. Varying the value of a significant parameter, numerical tests suggest two different types of contact inhibition between the cell populations: the two populations move with constant velocity and exhibit spatial segregation, or they stop to move and regions of coexistence are formed. In order to understand the different mechanisms, we prove that there exists a segregated traveling wave solution for a unique wave speed, and we present numerical results on the "stability" of the segregated waves. We conjecture the existence of a non-segregated standing wave for certain parameter values.
2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MAT/07 - FISICA MATEMATICA
English
Con Impact Factor ISI
http://dx.doi.org/10.3934/nhm.2013.8.131
Bertsch, M., Mimura, M., Wakasa, T. (2013). Modeling contact inhibition of growth: traveling waves. NETWORKS AND HETEROGENEOUS MEDIA, 8(1), 131-147 [10.3934/nhm.2013.8.131].
Bertsch, M; Mimura, M; Wakasa, T
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/117774
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