Sclerosis and reduced microvessel density characterize advanced stages of muscular dystrophy and hamper cell or gene delivery, precluding treatment of most individuals with Duchenne muscular dystrophy. Modified tendon fibroblasts expressing an angiogenic factor (placenta growth factor, PlGF) and a metalloproteinase (matrix metalloproteinase-9, MMP-9) are able to restore a vascular network and reduce collagen deposition, allowing efficient cell therapy in aged dystrophic mice. These data open the possibility of extending new therapies to currently untreatable individuals.
Gargioli, C., Coletta, M., De Grandis, F., Cannata, S., Cossu, G. (2008). PLGF-MMP9 expressing cells restore microcirculation and efficacy of cell terapy in old dystrophic muscle. NATURE MEDICINE, 14, 973-978 [10.1038/nm.1852].
PLGF-MMP9 expressing cells restore microcirculation and efficacy of cell terapy in old dystrophic muscle
GARGIOLI, CESARE;CANNATA, STEFANO;
2008-01-01
Abstract
Sclerosis and reduced microvessel density characterize advanced stages of muscular dystrophy and hamper cell or gene delivery, precluding treatment of most individuals with Duchenne muscular dystrophy. Modified tendon fibroblasts expressing an angiogenic factor (placenta growth factor, PlGF) and a metalloproteinase (matrix metalloproteinase-9, MMP-9) are able to restore a vascular network and reduce collagen deposition, allowing efficient cell therapy in aged dystrophic mice. These data open the possibility of extending new therapies to currently untreatable individuals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
