Eight elderly patients with relapsed or refractory acute myeloid leukemia were treated sequentially with recombinant human granulocyte colony-stimulating factor with rhG-CSF and Mylotarg. Priming with rhG-CSF in vivo induced an increase in the proportion of CD33+ cycling blasts. Four patients (50% ) achieved a complete remission, 2 patients had a partial remission and the other 2 were resistant.

Leone, G., Rutella, S., Voso, M.t., Fianchi, L., Scardocci, A., Pagano, L. (2004). In vivo priming with granulocyte colony-stimulating factor possibly enhances the effect of gemtuzumab-ozogamicin in acute myeloid leukemia: results of a pilot study. HAEMATOLOGICA, 89(5), 634-636.

In vivo priming with granulocyte colony-stimulating factor possibly enhances the effect of gemtuzumab-ozogamicin in acute myeloid leukemia: results of a pilot study

VOSO, MARIA TERESA;
2004-05-01

Abstract

Eight elderly patients with relapsed or refractory acute myeloid leukemia were treated sequentially with recombinant human granulocyte colony-stimulating factor with rhG-CSF and Mylotarg. Priming with rhG-CSF in vivo induced an increase in the proportion of CD33+ cycling blasts. Four patients (50% ) achieved a complete remission, 2 patients had a partial remission and the other 2 were resistant.
mag-2004
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Aged; Aminoglycosides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, CD; Drug Therapy, Combination; Granulocyte Colony-Stimulating Factor; Humans; Immunotoxins; Leukemia, Myeloid; Pilot Projects
Leone, G., Rutella, S., Voso, M.t., Fianchi, L., Scardocci, A., Pagano, L. (2004). In vivo priming with granulocyte colony-stimulating factor possibly enhances the effect of gemtuzumab-ozogamicin in acute myeloid leukemia: results of a pilot study. HAEMATOLOGICA, 89(5), 634-636.
Leone, G; Rutella, S; Voso, Mt; Fianchi, L; Scardocci, A; Pagano, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/115750
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