Polymorphisms in carcinogen- and drug-metabolizing enzymes may increase the risk of acute myeloid leukemia (AML) and may influence prognosis. We report that the polymorphic variant of the cytochrome P450 CYP1A1*2A, present in 11.3% of patients, is an independent unfavorable prognostic factor for failure-free and overall survival in patients with AML.

Voso, M.t., D'Alo', F., Gumiero, D., Guidi, F., Hohaus, S., Leone, G. (2005). The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia. HAEMATOLOGICA, 90(7), 982-984.

The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia

VOSO, MARIA TERESA;
2005-07-01

Abstract

Polymorphisms in carcinogen- and drug-metabolizing enzymes may increase the risk of acute myeloid leukemia (AML) and may influence prognosis. We report that the polymorphic variant of the cytochrome P450 CYP1A1*2A, present in 11.3% of patients, is an independent unfavorable prognostic factor for failure-free and overall survival in patients with AML.
lug-2005
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Acute Disease; Cytochrome P-450 CYP1A1; Cytogenetics; Disease-Free Survival; Leukemia, Myeloid, Acute; Polymorphism, Genetic; Prognosis; Remission Induction; Risk; Treatment Outcome; Alleles; Genetic Predisposition to Disease
Voso, M.t., D'Alo', F., Gumiero, D., Guidi, F., Hohaus, S., Leone, G. (2005). The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia. HAEMATOLOGICA, 90(7), 982-984.
Voso, Mt; D'Alo', F; Gumiero, D; Guidi, F; Hohaus, S; Leone, G
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/115735
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