Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP-ribose) polymerase (PARP) inhibitors. The ataxia telangiectasia mutated (ATM) kinase is a key DDR protein whose heterozygous germline mutation is a moderate-risk factor for developing breast cancer. In this study, we examined whether ATM inactivation in breast cancer cell lines confers sensitivity to PARP inhibitors.
Gilardini Montani, M., Prodosmo, A., Stagni, V., Merli, D., Monteonofrio, L., Gatti, V., et al. (2013). ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 32(1), 95 [10.1186/1756-9966-32-95].
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition
BARILA', DANIELA;
2013-01-01
Abstract
Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP-ribose) polymerase (PARP) inhibitors. The ataxia telangiectasia mutated (ATM) kinase is a key DDR protein whose heterozygous germline mutation is a moderate-risk factor for developing breast cancer. In this study, we examined whether ATM inactivation in breast cancer cell lines confers sensitivity to PARP inhibitors.| File | Dimensione | Formato | |
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