The dual PDE3/4 inhibitor RPL 554 causes bronchodilation in patients with asthma or COPD and synergistically interacts with muscarinic receptor antagonists in relaxing human isolated bronchi in acute experimental settings. In the present study we investigated the long-lasting interaction between RPL554 and glycopyrronium by testing these drugs for their ability to relax both medium and small human isolated bronchi.

Calzetta, L., Cazzola, M., Page, C., Rogliani, P., Facciolo, F., Matera, M. (2015). Pharmacological characterization of the interaction between the dual phosphodiesterase (PDE) 3/4 inhibitor RPL554 and glycopyrronium on human isolated bronchi and small airways. PULMONARY PHARMACOLOGY & THERAPEUTICS, 32, 15-23 [10.1016/j.pupt.2015.03.007].

Pharmacological characterization of the interaction between the dual phosphodiesterase (PDE) 3/4 inhibitor RPL554 and glycopyrronium on human isolated bronchi and small airways

CAZZOLA, MARIO;ROGLIANI, PAOLA;
2015-01-01

Abstract

The dual PDE3/4 inhibitor RPL 554 causes bronchodilation in patients with asthma or COPD and synergistically interacts with muscarinic receptor antagonists in relaxing human isolated bronchi in acute experimental settings. In the present study we investigated the long-lasting interaction between RPL554 and glycopyrronium by testing these drugs for their ability to relax both medium and small human isolated bronchi.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
English
Airway smooth muscle; Asthma; COPD; Glycopyrronium; Human isolated bronchi; RPL554; Relaxant response; Small airways; Synergistic interaction
Calzetta, L., Cazzola, M., Page, C., Rogliani, P., Facciolo, F., Matera, M. (2015). Pharmacological characterization of the interaction between the dual phosphodiesterase (PDE) 3/4 inhibitor RPL554 and glycopyrronium on human isolated bronchi and small airways. PULMONARY PHARMACOLOGY & THERAPEUTICS, 32, 15-23 [10.1016/j.pupt.2015.03.007].
Calzetta, L; Cazzola, M; Page, C; Rogliani, P; Facciolo, F; Matera, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/115097
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