Fifty-nine secondary metabolites have been isolated from Cydonia vulgaris peels and characterised on the basis of their spectroscopic features. Among them, five metabolites, 3b-(18-hydroxylinoleoyl)-28- hydroxyurs-12-ene (12), 3b-linoleoylurs-12-en-28-oic acid (15), 3b-oleoyl-24-hydroxy-24-ethylcholesta- 5,28(29)-diene (24), tiglic acid 1-O-b-D-glucopyranoside (35), and 6,9-dihydroxymegastigmasta-5, 7-dien-3-one 9-O-b-D-gentiobioside (46), have been isolated and elucidated for the first time. All of the compounds were tested for their radical-scavenging and antioxidant activities by measuring their capacity to scavenge the 2,20-diphenyl-1-picrylhydrazyl (DPPH) radical, and anion superoxide radical and to induce the reduction of Mo(VI) to Mo(V). The antiproliferative activity of all the most abundant compounds by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) bioassay on murine B16-F1 melanoma cells has been also assessed.
Alesiani, D., Canini, A., D'Abrosca, B., Dellagreca, M., Fiorentino, A., Mastellone, C., et al. (2010). Antioxidant and antiproliferative activities of phytochemicals from Quince (Cydonia vulgaris) peels. FOOD CHEMISTRY, 118(2), 199-207 [doi:10.1016/j.foodchem.2009.04.098].
Antioxidant and antiproliferative activities of phytochemicals from Quince (Cydonia vulgaris) peels
CANINI, ANTONELLA;
2010-01-01
Abstract
Fifty-nine secondary metabolites have been isolated from Cydonia vulgaris peels and characterised on the basis of their spectroscopic features. Among them, five metabolites, 3b-(18-hydroxylinoleoyl)-28- hydroxyurs-12-ene (12), 3b-linoleoylurs-12-en-28-oic acid (15), 3b-oleoyl-24-hydroxy-24-ethylcholesta- 5,28(29)-diene (24), tiglic acid 1-O-b-D-glucopyranoside (35), and 6,9-dihydroxymegastigmasta-5, 7-dien-3-one 9-O-b-D-gentiobioside (46), have been isolated and elucidated for the first time. All of the compounds were tested for their radical-scavenging and antioxidant activities by measuring their capacity to scavenge the 2,20-diphenyl-1-picrylhydrazyl (DPPH) radical, and anion superoxide radical and to induce the reduction of Mo(VI) to Mo(V). The antiproliferative activity of all the most abundant compounds by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) bioassay on murine B16-F1 melanoma cells has been also assessed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
