In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus (HCV) genotype 1 infection.

Afdhal, N., Zeuzem, S., Kwo, P., Chojkier, M., Gitlin, N., Puoti, M., et al. (2014). Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. THE NEW ENGLAND JOURNAL OF MEDICINE, 370(20), 1889-1898 [10.1056/NEJMoa1402454].

Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection

AGARWAL, GAURAV KUMAR;
2014-01-01

Abstract

In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus (HCV) genotype 1 infection.
2014
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
Con Impact Factor ISI
Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Benzimidazoles; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Fluorenes; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; RNA, Viral; Ribavirin; Uridine Monophosphate; Viral Load; Young Adult
Afdhal, N., Zeuzem, S., Kwo, P., Chojkier, M., Gitlin, N., Puoti, M., et al. (2014). Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. THE NEW ENGLAND JOURNAL OF MEDICINE, 370(20), 1889-1898 [10.1056/NEJMoa1402454].
Afdhal, N; Zeuzem, S; Kwo, P; Chojkier, M; Gitlin, N; Puoti, M; Romero Gomez, M; Zarski, J; Agarwal, Gk; Buggisch, P; Foster, G; Brau, N; Buti, M; Jacobson, I; Subramanian, G; Ding, X; Mo, H; Yang, J; Pang, P; Symonds, W; Mchutchison, J; Muir, A; Mangia, A; Marcellin, P; Angelico, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/114040
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